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Allotype (immunology)

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Title: Allotype (immunology)  
Author: World Heritage Encyclopedia
Language: English
Subject: Idiotype, Genetics, Clonal deletion, Conformational epitope, Isotype (immunology)
Collection: Genetics, Transplantation Medicine
Publisher: World Heritage Encyclopedia

Allotype (immunology)

The allotype affects the constant region (labeled CL and CH1-3 in the diagram.)

In immunology, an immunoglobulin allotype is the allele of the antibody chains found in the individual. The word allotype comes from two Greek roots, allo meaning 'other or differing from the norm' and typos meaning 'mark.' Thus allotype refers to the idea that each immunoglobin has unique sequences particular to the individual's genome that manifest in its constant region (normally).

To reduce risk of transplant rejection, tissue typing is used to try to match donors and recipients with the same or similar allotypes.

The most important types are Gm (heavy chain) and km (light chain).

It can be used in resolving paternity disputes.[1]

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