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Title: Rs6311  
Author: World Heritage Encyclopedia
Language: English
Subject: Single-nucleotide polymorphisms, Rs6313, Single-nucleotide polymorphism
Collection: Single-Nucleotide Polymorphisms
Publisher: World Heritage Encyclopedia


SNP: Rs6311
Name(s) -1438G/A, -1438A/G, A-1438G, G-1428A
Gene HTR2A
Chromosome 13
External databases
Ensembl Human SNPView
dbSNP 6311
HapMap 6311
SNPedia 6311
HgenetInfoDB 6311
SzGene Meta-analysis Overview

In genetics rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character Inventory[1][2][3][4] or with a psychological task measuring impulsive behavior.[5] The SNP has also been investigated in rheumatology studies.[6][7]

Some research studies may refer to this gene variation as a C/T SNP,[2] while others refer to it as a G/A polymorphism in the promoter region, thus writing it as, e.g., −1438 G/A or 1438G>A.[8][9][10]

As of 2008, meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.[11]

rs6313, rs6314, and rs7997012 are other investigated SNPs in the HTR2A gene.


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