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Calcrl

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Title: Calcrl  
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Subject: Calcitonin gene-related peptide, Adrenomedullin, Receptor activity-modifying protein, RAMP1, RAMP2, RAMP3
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Calcrl

Calcitonin receptor-like
Available structures
PDB Ortholog search: RCSB
Identifiers
CALCRL Gene
RNA expression pattern

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.[2]

Function

The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CALCRL with different RAMP proteins produces different receptors:[3][4]

These receptors are linked to the G protein Gs,[6] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).

Structure

CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.[1]

References


Further reading

External links

  • Medical Subject Headings (MeSH)
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