This article will be permanently flagged as inappropriate and made unaccessible to everyone. Are you certain this article is inappropriate? Excessive Violence Sexual Content Political / Social
Email Address:
Article Id: WHEBN0011782995 Reproduction Date:
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
O(c1c(cccc1)C2CC2)CC/3=N/CCN\3
InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) YKey: YAORIDZYZDUZCM-UHFFFAOYSA-N Y
InChI=1/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)Key: YAORIDZYZDUZCM-UHFFFAOYAV
Cirazoline is a nonselective agonist of the alpha-1 adrenergic receptor (α1-AR), and an antagonist to the alpha-2 adrenergic receptor.[1] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[1]
Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1-adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[2]
* Note that many TCAs, TeCAs, antipsychotics, ergolines, and some piperazines like buspirone and trazodone all antagonize α1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
* Note that many atypical antipsychotics and azapirones like buspirone (via metabolite 1-PP) antagonize α2-adrenergic receptors as well.
* Note that MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
Norepinephrine, Epinephrine, Methamphetamine, Isoprenaline, Calcium
Amphetamine, Methamphetamine, Norepinephrine, Decongestant, Skin
Norepinephrine, Methamphetamine, Central nervous system, Mianserin, Amphetamine