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Coenzyme F420

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Title: Coenzyme F420  
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Subject: Cofactor (biochemistry), Flavins, Coenzymes, Heme O, Heme B
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Coenzyme F420

Structure of Coenzyme F420

Coenzyme F420 or 8-hydroxy-5-deazaflavin is a coenzyme involved in redox reactions in methanogens,[1] in many Actinobacteria, and sporadically in other bacterial lineages. It is a flavin derivative. The coenzyme is a substrate for coenzyme F420 hydrogenase,[2] 5,10-methylenetetrahydromethanopterin reductase and methylenetetrahydromethanopterin dehydrogenase.[3][4]

A particularly rich natural source of F420 is Mycobacterium smegmatis, in which several dozen enzymes use F420 instead of the related cofactor FMN used by homologous enzymes in most other species.[5]

See also


  1. ^ Deppenmeier U (2002). "Redox-driven proton translocation in methanogenic Archaea". Cell. Mol. Life Sci. 59 (9): 1513–33.  
  2. ^ Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT (1987). "8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization". Biochemistry. 26 (14): 4219–27.  
  3. ^ Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U (2003). "Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary [sic] structure". J. Mol. Biol. 332 (5): 1047–57.  
  4. ^ GD; Geerts, WJ; Keltjens, JT; Van Der Drift, C; Vogels, GD (1991). "Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri". Biochim. Biophys. Acta. 1079 (3): 293–302.  
  5. ^ Selengut JD, Haft DH (2010). "Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria.". J Bacteriol. 192 (21): 5788–98.  

External links

  • KEGG entry for F420
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