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Title: Denopamine  
Author: World Heritage Encyclopedia
Language: English
Subject: Fencamine, 3,4-Dimethylmethcathinone, 4-Fluoromethamphetamine, Ethylnorepinephrine, 3-Fluoromethcathinone
Collection: Alcohols, Beta1-Adrenergic Agonists, Phenethylamines, Phenol Ethers, Phenols
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • (Prescription only)
Routes of
CAS Registry Number
ATC code None
PubChem CID:
Chemical data
Formula C18H23NO4
Molecular mass 317.37 g/mol

Denopamine (INN) is a cardiotonic drug which acts as a Beta-1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4]


  1. ^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
  2. ^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
  3. ^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
  4. ^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398
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