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Dicycloverine

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Title: Dicycloverine  
Author: World Heritage Encyclopedia
Language: English
Subject: Muscarinic acetylcholine receptor, Hyoscyamine, Anticholinergic, Salvinorin A, Atropine
Collection: Amines, Antispasmodics, Carboxylate Esters, Cyclohexanecarboxylic Acids, Muscarinic Antagonists
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Dicycloverine

Dicycloverine
Systematic (IUPAC) name
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
Clinical data
Trade names Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/Drugs.com
MedlinePlus
Pregnancy
category
  • AU: B1
  • US: B (No risk in non-human studies)
Legal status
Pharmacokinetic data
Protein binding >99%
Biological half-life 5 h
Identifiers
CAS Registry Number  Y
ATC code A03
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Chemical data
Formula C19H35NO2
Molecular mass 309.487 g/mol
 Y   

Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.[1]

Contents

  • Medical uses 1
  • Side effects 2
  • Caution 3
  • See also 4
  • References 5
  • Further reading 6
  • External links 7

Medical uses

A 10-mg oral capsule of dicyclomine hydrochloride, manufactured by Mylan

Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[2]

In the UK, it is an ingredient of a multiple-ingredient preparation, with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon. In France, it is an ingredient of a multiple-ingredient preparation, with colchicine, under the brand Colchimax. In India, it is of a compound with paracetamol under the trade name Cyclopam. It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic. Also it is a part of Normaxin containing two other salts clidinium bromide and chlordiazepoxide.

Side effects

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.[2] Recreational use of this drug for its anticholinergic effects (both low dose for euphoria and high dose for delirium) has been rarely reported; it is also reputed to cause a rapid increase in libido in the first 10-135 minutes after dosing.

Caution

Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[2]

See also

References

  1. ^ Tilford, C. H.; Campen, M. G. V.; Shelton, R. S. (1947). "Aminoesters of Substituted Alicylic Carboxylic Acids1". Journal of the American Chemical Society 69 (11): 2902.  
  2. ^ a b c "Dicyclomine hydrochloride". Monograph. Drugs.com. 

Further reading

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

External links

  • "Dicyclomine". Medicine Net. 
  • "Dicyclomine". Medline Plus. 
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