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Title: Echinopsidine  
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Subject: D-161, Sercloremine, Monoaminergic, Deserpidine, Methylenedioxyethylamphetamine
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Skeletal formula of echinopsidine
Systematic (IUPAC) name
Clinical data
Legal status
  • Prescription only
Routes Oral
CAS number
58916-73-7 (hydroiodide)
ATC code None
Synonyms Echinopsidine Iodide
Chemical data
Formula C10H12N2 
Mol. mass 160.22 g/mol

Echinopsidine (Adepren) is an antidepressant that was under development in Bulgaria for the treatment of depression.[1][2] It increases serotonin, norepinephrine, and dopamine levels in the brain and is believed to act as a monoamine oxidase inhibitor (MAOI).[3][4][5] Echinopsidine is found naturally in Echinops echinatus along with the related alkaloids echinopsine and echinozolinone.[6]

See also


  1. ^ Guliamov MG (1982). "[Experience with the use of new Bulgarian psychotropic drugs]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) (in Russian) 82 (11): 115–22.  
  2. ^ Guliamov MG (1986). "[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) (in Russian) 86 (4): 582–7.  
  3. ^ Tiutiulkova N, Gorancheva Iu (1978). "[Effect of adepren on the cerebral concentration of serotonin]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian) 17 (2): 83–5.  
  4. ^ Stefanova D, Tiutiulkova N, Nikolova M (1976). "[Effect of adepren on the behavior and brain catecholamines of rats in an open field setup]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian) 15 (1): 42–6.  
  5. ^ Tiutiulkova NI, Gorancheva IuI (1975). "[Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian) 14 (4): 187–9.  
  6. ^ Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. 2007.  

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