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Famprofazone

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Famprofazone

Famprofazone
Systematic (IUPAC) name
1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3H-pyrazol-3-one
Clinical data
Legal status
  • ℞ Prescription only
Routes Oral
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
Chemical data
Formula C24H31N3O 
Mol. mass 377.52 g/mol

Famprofazone (Gewodin, Gewolen) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing false positives on drug tests for amphetamines.[3]

See also

References

  1. ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932.  
  2. ^ a b Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342.  
  3. ^ a b Chan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse". Journal of Analytical Toxicology 34 (6): 347–53.  
  4. ^ Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man". Xenobiotica 22 (3): 377–84.  
  5. ^ Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998). "Identification of new urinary metabolites of famprofazone in humans". Journal of Analytical Toxicology 22 (1): 55–60.  
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolidines
Salicylates
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
(profens)
N-Arylanthranilic acids
(fenamates)
Coxibs
Other
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.

: MUS, DF+DRCT

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noco (, , )/ ()/, /,

, drug (/)

Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
Phenylalkylpyrrolidines
Catecholamines
(and close relatives)
Miscellaneous
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