Fluparoxan (GR-50,360) is a potent and highly selective α2-adrenergic receptor antagonist which was being investigated as an antidepressant but failed to show sufficiently significant efficacy for depression in clinical trials and never made it to the market.[1][2] In animal and/or human studies fluparoxan has been found to produce stimulation, tachycardia, hypertension, hyperthermia, penile erection, and pro-nociceptive effects, as well as antidepressant-like effects, panic, and anxiogenesis.[1][2][3][4]

See also


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.