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Glucose 1-phosphate

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Glucose 1-phosphate

Glucose 1-phosphate

Anionic form of α-D-glucose 1-phosphate

Neutral form of α-D-glucose 1-phosphate
Names
IUPAC name
Glucose 1-phosphate
Other names
Cori ester
Identifiers
 YesY
ChEBI  YesY
ChemSpider  YesY
Jmol-3D images Image
MeSH
PubChem
Properties
C6H13O9P
Molar mass 260.13 g·mol−1
 YesY  (: YesY/N?)

Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form.

Contents

  • Reactions of α-glucose 1-phosphate 1
    • Catabolic 1.1
    • Anabolic 1.2
  • β-Glucose 1-phosphate 2
  • See also 3

Reactions of α-glucose 1-phosphate

Catabolic

In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure.

To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase. One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism.

Anabolic

In glycogenesis, free glucose 1-phosphate can also react with UTP to form UDP-glucose, by using the enzyme UDP-glucose pyrophosphorylase. It can then return to the greater glycogen structure via glycogen synthase.

β-Glucose 1-phosphate

β-Glucose 1-phosphate is found in some microbes. It is produced by inverting α-glucan phosphorylases including maltose phosphorylase, kojibiose phosphorylase and trehalose phosphorylase and is then converted into glucose 6-phosphate by β-phosphoglucomutase.

See also

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