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Glucose 1-phosphate

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Title: Glucose 1-phosphate  
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Subject: Gerty Cori, Metabolic intermediate, Phosphoglucomutase, Monosaccharide derivatives, Galactokinase
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Glucose 1-phosphate

Glucose 1-phosphate

Anionic form of α-D-glucose 1-phosphate

Neutral form of α-D-glucose 1-phosphate
IUPAC name
Glucose 1-phosphate
Other names
Cori ester
ChemSpider  YesY
Jmol-3D images Image
Molar mass 260.13 g·mol−1
 YesY  (: YesY/N?)

Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form.


  • Reactions of α-glucose 1-phosphate 1
    • Catabolic 1.1
    • Anabolic 1.2
  • β-Glucose 1-phosphate 2
  • See also 3

Reactions of α-glucose 1-phosphate


In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure.

To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase. One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism.


In glycogenesis, free glucose 1-phosphate can also react with UTP to form UDP-glucose, by using the enzyme UDP-glucose pyrophosphorylase. It can then return to the greater glycogen structure via glycogen synthase.

β-Glucose 1-phosphate

β-Glucose 1-phosphate is found in some microbes. It is produced by inverting α-glucan phosphorylases including maltose phosphorylase, kojibiose phosphorylase and trehalose phosphorylase and is then converted into glucose 6-phosphate by β-phosphoglucomutase.

See also

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