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Title: Isopropamide  
Author: World Heritage Encyclopedia
Language: English
Subject: Janssen Pharmaceutica, Acotiamide, Asimadoline, Cinitapride, Fedotozine
Collection: Amides, Anticholinergics, Belgian Inventions, Janssen Pharmaceutica, Quaternary Ammonium Compounds
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
  • US: Rx-only, Unscheduled
  • Unscheduled
Routes of
CAS Registry Number  N
ATC code A03
PubChem CID:
DrugBank  YesY
ChemSpider  YesY
Chemical data
Formula C23H33N2O+
Molecular mass 353.52092 g/mol

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.


  • Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
  • Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

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