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Lefetamine

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Lefetamine

Lefetamine
Systematic (IUPAC) name
(1R)-N,N-dimethyl-1,2-diphenylethanamine
Clinical data
Legal status
Routes of
administration
Oral
Identifiers
CAS Registry Number  N
ATC code None
PubChem CID:
ChemSpider  YesY
UNII  YesY
Chemical data
Formula C16H19N
Molecular mass 225.329 g/mol
 N   

Lefetamine (Santenol) is a drug which is a stimulant and also an analgesic with effects comparable to codeine.

Lefetamine-related 1,2-diphenylethylamines were invented in the 1940s and showed weak analgesic activity.[1]

It was investigated in Japan in 1950s.[2] The l-isomere showed weak analgetic action comparable to codeine and antitussive action far weaker than codeine. The d-isomer showed no such activity but caused seizures in rats.[3][4]

It was abused in Japan during the 1950s. In a small study in 1989 it showed some effect against opioid withdrawal symptoms without causing withdrawal symptoms itself. It was concluded that it may be an opioid partial agonist.[5]

It has been abused in Europe, in 1989 a small study of 15 abusers and some volunteers found, that it had some partial similarity to opioids, that it produced withdrawal symptoms and had dependence and abuse potential to a certain degree.[6]

In a small study in 1994 it was compared to clonidine and buprenorphine for the detoxification of methadone patients and found to be inferior to both for this purpose.[7]

Research

Some related pyrrylphenylethanones had analgetic activity comparable to morphine.[8] Some pyrrole analogues were reported to have analgetic effects comparable to lefetamine and being devoid of neurotoxic properties.[9]

See also

References

  1. ^
  2. ^ DE patent 1159958, Ogyu, K.; Fujimura H.; Yamakawa Y.; Mita I., "Verfahren zur Herstellung von antitussiv wirksamem l-1,2-Diphenyl-1-dimethylaminoaethan und dessen Salzen", issued 1963-12-27, assigned to Institut Seikatsu Kagaku Kenkyusho (Scientific Research Institute for Practical Life, Kyoto) 
  3. ^
  4. ^
  5. ^
  6. ^
  7. ^
  8. ^
  9. ^
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