World Library  
Flag as Inappropriate
Email this Article


Article Id: WHEBN0023272105
Reproduction Date:

Title: Litoxetine  
Author: World Heritage Encyclopedia
Language: English
Subject: PNU-142633, PHA-57378, PNU-181731, E-55888, LP-44
Collection: Antidepressants, Ethers, Naphthalenes, Piperidines, Serotonin Reuptake Inhibitors
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number
ATC code None
Chemical data
Formula C16H19NO 
Mol. mass 241.327 g/mol

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s.[1] It acts as a serotonin reuptake inhibitor and 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine for medicinal use was apparently halted in the late 1990s.


  1. ^ Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology 40 (2): 119–25.  
  2. ^ Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology 232 (2-3): 139–45.  

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.