MAS1 oncogene

MAS1 oncogene
Identifiers
Symbol MAS1
Entrez HUGO OMIM RefSeq UniProt Locus q24-q27
MAS1 oncogene-like
Identifiers
Symbol MAS1L
Entrez HUGO OMIM RefSeq UniProt Locus p21

The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite angiotensin-(1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4]

References

External links

  • IUPHAR GPCR Database - MAS1
  • IUPHAR GPCR Database - MAS1L
  • Medical Subject Headings (MeSH)
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