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Pneumocystis jirovecii

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Title: Pneumocystis jirovecii  
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Pneumocystis jirovecii

Pneumocystis
P. jiroveci cysts in tissue
Scientific classification
Kingdom: Fungi
Phylum: Ascomycota
Class: Pneumocystidomycetes
Order: Pneumocystidales
Family: Pneumocystidaceae
Genus: Pneumocystis
Species: P. jiroveci
Binomial name
Pneumocystis jiroveci
J.K.Frenkel

Pneumocystis jirovecii is a yeast-like pneumoniaPneumocystis, it is an important human pathogen, particularly among immunocompromised hosts. Prior to its discovery as a human-specific pathogen, P. jiroveci was known as P. carinii.

Contents

  • Lifecycle 1
  • Medical relevance 2
  • Nomenclature 3
  • Pneumocystis genome 4
  • History 5
  • References 6

Lifecycle

The complete lifecycles of any of the species of Pneumocystis are not known, but presumably all resemble the others in the genus. The terminology follows zoological terms, rather than mycological terms, reflecting the initial misdetermination as a protozoan parasite. It is an extracellular parasite. All stages are found in lungs and because they cannot be cultured ex vivo, direct observation of living Pneumocystis is difficult. The trophozoite stage is thought to be equivalent to the so-called vegetative state of other species (such as Schizosaccharomyces pombe) which, like Pneumocystis belong to the Taphrinomycotina branch of the fungal kingdom.[1] The trophozoite stage is single-celled and appears amoeboid (multilobed) and closely associated with host cells. Globular cysts eventually form that have a thicker wall. Within these ascus-like cysts, eight spores form which are released through rupture of the cyst wall. The cysts often collapse forming crescent-shaped bodies visible in stained tissue. It is not known for certain if meiosis takes place within the cysts, or what the genetic status is of the various cell types.[2]

Medical relevance

Pneumocystis pneumonia is an important disease of immunocompromised humans, particularly patients with HIV, but also patients with an immune system that is severely suppressed for other reasons; for example, following a bone marrow transplant. In humans with a normal immune system, it is an extremely common silent infection.[3]

Identified by methenamine silver stain of lung tissue. Type I pneumocytes, and Type II pneumocytes overreplicate and damage alveolar epithelium, causing death by asphyxiation. Fluid leaks into alveoli producing an exudate seen as honeycomb/cotton candy appearance on hematoxylin and eosin stained slides. Drug of choice is TMP-SMX, pentamidine, or dapsone. In HIV patients, most cases occur when the CD4 count is below 200 cells per microliter.

Nomenclature

At first, the name Pneumocystis carinii was applied to the organisms found in both rats and humans, as it was not yet known that the parasite was Otto Jirovec, who described Pneumocystis pneumonia in humans in 1952. After DNA analysis showed significant differences in the human variant, the proposal was made again in 1999 and has come into common use.[4]

The name was spelled according to the

  1. ^ a b James TY, et al. (2006). "Reconstructing the early evolution of Fungi using a six-gene phylogeny". Nature 443 (7113): 818–822.  
  2. ^ "see DPDx life-cycle diagram". Dpd.cdc.gov. Retrieved 2013-03-26. 
  3. ^ Ponce CA, Gallo M, Bustamante R, Vargas SL (2010). "Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population". Clin Infect Dis 50 (3): 347–353.  
  4. ^ Stringer JR, Beard CB, Miller RF, Wakefield AE (2002). "A New Name for Pneumocystis from Humans and New Perspectives on the Host-Pathogen Relationship". Emerg Infect Dis 8 (9): 891–6.  
  5. ^ Stringer JR, Beard CB, Miller RF Spelling Pneumocystis jiroveci Emerg Infect Dis. March 2009; doi:10.3201/eid1503.081060
  6. ^ "ICBN Recommendation 60C.1". If the personal name ends with a consonant (except -er),  
  7. ^ http://www.iapt-taxon.org/nomen/main.php. 
  8. ^ a b c d Redhead SA, Cushion MT, Frenkel JK, Stringer JR (2006). "Pneumocystis and Trypanosoma cruzi: nomenclature and typifications". J Eukaryot Microbiol 53 (1): 2–11.  
  9. ^ "Pneumocystis Genome Project". Pgp.cchmc.org. Retrieved 2013-03-26. 
  10. ^ Cissé OH, Pagni M, Hauser PM (2012) De novo assembly of the Pneumocystis jiroveci genome from a single bronchoalveolar lavage fluid specimen from a patient. MBio 4(1). pii: e00428-12. doi:10.1128/mBio.00428-12
  11. ^ Chagas C (1909). "Neue Trypanosomen". Vorläufige Mitteilung. Arch. Schiff. Tropenhyg. 13: 120–122. 
  12. ^ Chagas C (1909). "Nova tripanozomiase humana: Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem". Mem Inst Oswaldo Cruz 1 (2): 159–218.  
  13. ^ Carini A. (1910). "Formas des eschizogonia do Trypanosoma lewisi". Soc Med Cir São Paulo 38 (8): –. 
  14. ^ Delanoë P, Delanoë M. (1912). "Sur les rapports des kystes de Carini du poumon des rats avec le Trypanosoma lewisi". Comptes rendus de l'Academie des sciences 155: 658–61. 
  15. ^ van der Meer MG, Brug SL. (1942). "Infection à Pneumocystis chez l'homme et chez les animaux". Amer Soc Belge Méd Trop 22: 301–9. 
  16. ^ Vanek J. (1951). "Atypicka (interstitiálni) pneumonie detí vyvolaná Pneumocystis carinii (Atypical interstitial pneumonia of infants produced by Pneumocystis carinii)". Casop lék cesk 90: 1121–4. 
  17. ^ Jírovec O. (1952). "Pneumocystis carinii puvodce t. zv intertitialnich plasmocelularnich pneumonii kojencw (Pneumocystis carinii, the cause of interstitial plasmacellular pneumonia in neonates)". P Csl. Hyg epid mikrob 1: 141. 
  18. ^ Vanek J, Jírovec O, Lukes J. (1953). "Interstitial plasma cell pneumonia in infants". Ann Paediatrici 180: 1–21. 
  19. ^ Gajdusek DC (1957). "Pneumocystis carinii; etiologic agent of interstitial plasma cell pneumonia of premature and young infants". Pediatrics 19: 543–65. 
  20. ^ Frenkel JK (1976). "Pneumocystis jiroveci n. sp. from man: morphology, physiology, and immunology in relation to pathology". Natl Cancer Inst Monogr 43: 13–27.  
  21. ^ Gigliotti F (2005). "Pneumocystis carinii: has the name really been changed?". Clin Infect Dis 41 (12): 1752–5.  
  22. ^ Hawksworth DL (2007). "Responsibility in naming pathogens: the case of Pneumocystis jiroveci, the causal agent of pneumocystis pneumonia". Lancet Infect. Dis. 7 (1): 3–5.  
  23. ^ Hugot J, Demanche C, Barriel V, Dei-Cas E, Guillot J (2003). "Phylogenetic systematics and evolution of primate-derived Pneumocystis based on mitochondrial or nuclear DNA sequence comparison". Syst Biol 52 (6): 735–744.  
  24. ^ Keely S, Fischer J, Cushion M, Stringer J (2004). "Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice". Microbiology 150 (Pt 5): 1153–65.  
  25. ^ Cushion MT, Keely SP, Stringer JR (2004). "Molecular and phenotypic description of Pneumocystis wakefieldiae sp. nov., a new species in rats". Mycologia 96 (3): 429–438.  
  26. ^ Cushion MT, Keely SP, Stringer JR (2005). "Validation of the name Pneumocystis wakefieldiae". Mycologia 97: 268–268.  
  27. ^ Dei-Cas E, et al. (2006). "Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic bases". FEMS Micriobiol. Rev. 30 (6): 853–871.  
  28. ^ Aliouat-Denis, C-M.; et al. (2008). "Pneumocystis species, co-evolution and pathogenic power". Infection, Genetics and Evolution 8 (5): 708–726.  
  29. ^ Demanche C, et al. (2001). "Phylogeny of Pneumocystis carinii from 18 Primate Species Confirms Host Specificity and Suggests Coevolution". J. Clinical Microbiol. 39 (6): 2126–2133.  

References

Historical and even recent reports of P. carinii from humans are based upon older classifications (still used by many, or those still debating the recognition of distinct species in the genus Pneumocystis) which does not mean that the true P. carinii from rats actually infects humans. In an intermediate classification system, the various taxa in different mammals have been called formae speciales or forms. For example the human "form" was called Pneumocystis carinii f. [or f. sp.] hominis, while the original rat infecting form was called Pneumocystis carinii f. [or f. sp.] carinii. This terminology is still used by some researchers. The species of Pneumocystis originally seen by Chagas have not yet been named as distinct species.[8] Many other undescribed species presumably exist and those that have been detected in many mammals are only known from molecular sample detection from lung tissue or fluids, rather than by direct physical observation.[28][29] Currently, they are cryptic taxa.

Pneumocystis was redescribed as a human pathogen in 1942 by two Dutch investigators, van der Meer and Brug who found it in three new cases: a 3-month-old infant with P. carinii" was the causative agent of pneumonia in these children.[16] The following year (1952) Jírovec reported "P. carinii" as the cause of interstitial pneumonia in neonates.[17][18][19] Following the realization that Pneumocystis from humans could not infect experimental animals such as rats, and that the rat form of Pneumocystis differed physiologically and had different antigenic properties, Frenkel[20] was the first to recognize the human pathogen as a distinct species. He named it "Pneumocystis jiroveci" (corrected to P. jiroveci - see nomenclature above). There has been controversy over the relabeling of P. carinii in humans as P. jiroveci,[8][21] which is why both names still appear in publications. However, only the name P. jiroveci is used exclusively for the human pathogen, whereas the name P. carinii has had a broader application to many species.[22] Frenkel and those before him believed that all Pneumocystis were protozoans, but soon afterwards evidence began accumulating that Pneumocystis was a fungal genus. Recent studies show it to be an unusual, in some ways a primitive genus of Ascomycota, related to a group of yeasts.[1] Every tested primate, including humans, appears to have its own type of Pneumocystis that is incapable of cross-infecting other host species and has co-evolved with each mammal species.[23] Currently only 5 species have been formally named: P. jiroveci from humans, P. carinii as originally named from rats, P. murina from mice,[24] P. wakefieldiae[25][26] also from rats, and P. oryctolagi from rabbits.[27]

The earliest report of this genus appears to have been that of trypanosome infecting humans.[12] The rediscovery of Pneumocystis cysts was reported by Antonio Carini in 1910 also in Brazil.[13] The genus was again discovered in 1912 by Delanoë and Delanoë this time at the Pasteur Institute in Paris, France who found it in rats and who proposed the genus and species name Pneumocystis carinii after Carini.[14]

History

The genome of P. jiroveci has been sequenced from a bronchoalveolar lavage sample.[10] The genome is small, low in G+C content and lacks most amino acid biosynthesis enzymes.

Pneumocystis species cannot be grown in culture. Therefore, there is a limitation to the availability of the human disease causing agent, P. jiroveci. Hence, investigation of the whole genome of a Pneumocystis is largely based upon true P. carinii available from experimental rats which can be maintained with infections. Genetic material of other species, such as P. jiroveci can be compared to the genome of P. carinii.[9]

Pneumocystis genome

The name P. carinii is incorrect for the human variant, but still describes the species found in rats and that name is typified by an isolate from rats.[8]

The term PCP, which was widely used by practitioners and patients, has been retained for convenience, with the rationale that it now stands for the more general Pneumocystis pneumonia rather than Pneumocystis carinii pneumonia.

[8] is typified (both lectotypified and epitypified) by samples from human autopsies dating from the 1960s. P. jiroveci as examples of the change in ICN Article 45, Ex 7. The name P. jiroveci and Pneumocystis A change in the ICNafp now recognizes the validity of the 1976 publication, making the 1999 proposal redundant, and cites [7] is correct.P. jirovecii Both spellings are commonly used, but according to the IBNafp [6]).ii (ICNafp), which requires such names be spelled with double i (International Code of Nomenclature for algae, fungi, and plants according to the [5]

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