World Library  
Flag as Inappropriate
Email this Article

Renal papillary necrosis

Article Id: WHEBN0008274506
Reproduction Date:

Title: Renal papillary necrosis  
Author: World Heritage Encyclopedia
Language: English
Subject: Nephrocalcinosis, Sickle-cell disease
Publisher: World Heritage Encyclopedia

Renal papillary necrosis

Renal papillary necrosis
Classification and external resources
ICD-10 N17.2
ICD-9 584.7
DiseasesDB 9572
MedlinePlus 000488
eMedicine med/2839 radio/523
MeSH D007681

Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla,[1] which is supplied by the vasa recta.

Signs and Symptoms

Renal papillary necrosis presents acutely with gross hematuria, flank pain, and tissue fragments in the urine. It may also include non-specific findings such as fever and chills. Alternatively, it can also present in a chronic form that remains asymptomatic and is diagnosed incidentally.[2]


Any condition that involves ischemia can lead to renal papillary necrosis. The four most significant causes are sickle cell disease or trait, analgesic use, diabetes mellitus, and severe pyelonephritis.[2]

A mnemonic for the causes of renal papillary necrosis is POSTCARDS: pyelonephritis, obstruction of the urogenital tract, sickle cell disease, tuberculosis, chronic liver disease, analgesia/alcohol abuse, renal transplant rejection, diabetes mellitus, and systemic vasculitis. Often, a patient with renal papillary necrosis will have numerous conditions acting synergistically to bring about the disease. [3][4]

Analgesic nephropathy is a cause of renal papillary necrosis.[5] The damage is cumulative and most patients of renal papillary necrosis would have ingested at least 2 kg of analgesics in the past. The risk is higher for phenacetin (which has been withdrawn from the market in the United States) and paracetamol (acetaminophen) compared to aspirin and other NSAIDs. Combination analgesic products, such as Goody's, also have a high risk of causing papillary necrosis.


  1. ^ Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH (2006). "Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography". Radiographics : a review publication of the Radiological Society of North America, Inc 26 (6): 1827–36. PMID 17102053. doi:10.1148/rg.266065039. 
  2. ^ a b Kumar, Vinay (2009). Robbins & Cotran Pathologic Basis of Disease. Saunders. 
  3. ^ Zadeii G, Lohr JW (June 1997). "Renal papillary necrosis in a patient with sickle cell trait". J. Am. Soc. Nephrol. 8 (6): 1034–9. PMID 9189873. 
  4. ^ Powell, Christopher. "Papillary Necrosis". Medscape Reference. Retrieved 10 Nov 2011. 
  5. ^ "Renal Pathology". Retrieved 2008-11-26. 

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.