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Rescinnamine

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Title: Rescinnamine  
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Subject: Sympatholytic, ACE inhibitors, Rauvolfia serpentina, ATC code C02, Antihypertensive agents
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Rescinnamine

Rescinnamine
Systematic (IUPAC) name
methyl (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}yohimban-16-carboxylate
Clinical data
Legal status
  • ℞ (Prescription only)
Routes of
administration 		oral
Identifiers
CAS Registry Number  Y
ATC code C02
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Synonyms methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4(9),5,7-tetraene-19-carboxylate
Chemical data
Formula C35H42N2O9
Molecular mass 634.716 g/mol
 Y   

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

It is an vinca alkaloid obtained from Rauwolfia serpentina[1] and other species of Rauwolfia.[2]

Brand names

Moderil, Cinnasil, Anaprel

References

  1. ^ FIFE R, MACLAURIN JC, WRIGHT JH (December 1960). "Rescinnamine in treatment of hypertension in hospital clinic and in general practice". British Medical Journal 2 (5216): 1848–50.  
  2. ^ Balsevich J, Constabel F, Kurz WG. (1982). "Alkaloids of Vinca major cv. Variegata.". Planta Med. 44 (2): 91–3.  
Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize α-adrenergic
vasoconstriction)
Central
α2 agonist
Adrenergic release inhibitors
Imidazoline receptor agonist
Ganglion-blocking/nicotinic antagonist
Peripheral
Indirect
MAOI
Adrenergic uptake inhibitor
Tyrosine hydroxylase inhibitor
Direct
α1 blockers
Non-selective α blocker
Other antagonists
Serotonin antagonist
Endothelin antagonist (for PH)
Index of the circulatory system
Description
  • Arteries
  • Veins
Disease
Treatment
  • Drugs
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