World Library  
Flag as Inappropriate
Email this Article

Rhodopsin-like receptors

Article Id: WHEBN0014567243
Reproduction Date:

Title: Rhodopsin-like receptors  
Author: World Heritage Encyclopedia
Language: English
Subject: G protein-coupled receptor, A5, Receptor (biochemistry), A12, Histamine H1 receptor, Proton-sensing G protein-coupled receptors
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Rhodopsin-like receptors

Rhodopsin-like receptors
Identifiers
Symbol 7tm_1
Pfam InterPro PROSITE PDOC00211
SCOP SUPERFAMILY OPM superfamily OPM protein 1gzm

Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors.[2]

Scope

G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine, and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. GPCRs are usually described as "superfamily" because they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence.[2] The currently known superfamily members include the rhodopsin-like GPCRs (this family), the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs.[3]

Function

The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormones, neurotransmitters, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices.[4][5][6]

Classes

Rhodopsin-like GPCRs have been classified into the following 19 subgroups (A1-A19) based on a phylogenetic analysis.[7]

Subfamily A1

  • IPR000355
    • CCR1, CKR1)
    • CCR2, CKR2)
    • CCR3, CKR3)
    • CCR4, CKR4)
    • CCR5, CKR5)
    • CCR8, CKR8)
    • CCRL2, CKRX)
  • IPR005393
  • IPR005387
  • GPR137B, TM7SF1)

Subfamily A2

  • IPR000355
    • CCRL1 CCRL1, CCR11)
    • CCR6, CKR6)
    • CCR7, CKR7)
    • CCR9, CKR9)
    • CCR10, CKRA)
  • IPR001053
    • CXCR3)
    • CXCR4, Fusin)
    • CXCR5)
    • CXCR6, BONZO)
    • IPR001416
  • IPR000174 (IL8R)
    • IL8RA, CXCR1)
    • IL8RB, CXCR2)
  • GPR182)
  • DARC, DUFF)
  • GPER, CML2, GPCR estrogen receptor)

Subfamily A3

  • IPR000248
    • AGTR1, AG2S)
    • AGTR2, AG22)
    • IPR003904
  • IPR000496
    • BDKRB1, BRB1)
    • BDKRB2, BRB2)
  • GPR15, GPRF)
  • GPR25)

Subfamily A4

  • IPR001418
    • delta Opioid receptor (OPRD1, OPRD)
    • kappa Opioid receptor (OPRK1, OPRK)
    • mu Opioid receptor (OPRM1, OPRM)
    • OPRL1, OPRX)
  • IPR000586
    • SSTR1, SSR1)
    • SSTR2, SSR2)
    • SSTR3, SSR3)
    • SSTR4, SSR4)
    • SSTR5, SSR5)
  • IPR009150
    • NPBWR1, GPR7)
    • NPBWR2, GPR8)
  • IPR002275

Subfamily A5

  • IPR000405
    • GALR1, GALR)
    • GALR2, GALS)
    • GALR3, GALT)
  • Cysteinyl leukotriene receptor IPR004071
    • CYSLTR1)
    • CYSLTR2)
  • IPR003981
    • LTB4R, P2Y7)
    • LTB4R2)
  • IPR008112
    • RXFP1, LGR7)
    • RXFP2, GPR106)
    • RXFP3, SALPR)
    • RXFP4, GPR100/GPR142)
  • IPR008103
  • IPR008361
  • IPR000670

Subfamily A6

  • IPR009126
    • CCKAR, CCKR)
    • CCKBR, GASR)
  • IPR005395
    • NPFFR1, FF1R)
    • NPFFR2, FF2R)
  • IPR000204
    • HCRTR1, OX1R)
    • HCRTR2, OX2R)
  • IPR001817
    • AVPR1A, V1AR)
    • AVPR1B, V1BR)
    • AVPR2, V2R)
  • IPR001658
  • QRFPR, GPR103)
  • GPR22, GPRM)
  • GPR176, GPR)

Subfamily A7

  • IPR001556
    • BRS3)
    • NMBR)
    • GRPR)
  • IPR000499
    • EDNRA, ET1R)
    • EDNRB, ETBR)
    • IPR003909
  • IPR005390
    • NMUR1)
    • NMUR2)
  • IPR003984
    • NTSR1, NTR1)
    • NTSR2, NTR2)
  • IPR009144
  • IPR003905
  • GPR39)
  • MLNR, GPR38)

Subfamily A8

  • IPR002234
    • C3AR1, C3AR)
    • C5AR1, C5AR)
    • IPR002258
  • IPR000826
    • FPR1, FMLR)
    • FPRL1, FML2)
    • FPRL2, FML1)
  • IPR000820
    • MAS1, MAS)
    • MAS1L, MRG)
  • GPR1)
  • GPR32, GPRW)
  • GPR44)
  • GPR77, C5L2)

Subfamily A9

  • IPR000025
    • MTNR1A, ML1A)
    • MTNR1B, ML1B)
  • IPR001681
    • TACR1, NK1R)
    • TACR2, NK2R)
    • TACR3, NK3R)
  • IPR000611
    • NPY1R, NY1R)
    • NPY2R, NY2R)
    • PPYR1, NY4R)
    • NPY5R, NY5R)
  • IPR001402
  • PROKR1, GPR73)
  • PROKR2, PKR2)
  • GPR19, GPRJ)
  • GPR50, ML1X)
  • GPR75)
  • GPR83, GPR72)

Subfamily A10

  • Glycoprotein hormone receptor IPR002131
    • FSH-receptor (FSHR)
    • LHCGR, LSHR)
    • TSHR)
  • LGR4, GPR48)
  • LGR5, GPR49)
  • LGR6)

Subfamily A11

  • IPR013312
    • FFAR1, GPR40)
    • FFAR2, GPR43)
    • FFAR3, GPR41)
    • GPR42, FFAR1L)
  • IPR002286
    • P2RY1)
    • P2RY2)
    • P2RY4)
    • P2RY6)
    • P2RY8)
    • P2RY11)
  • HCAR1, GPR81)
  • HCAR2, GPR109A)
  • HCAR3, GPR109B, HM74)
  • GPR31, GPRV)
  • GPR82)
  • OXGR1, GPR80)
  • SUCNR1, GPR91)

Subfamily A12

  • IPR002286
    • P2RY12)
    • IPR008109
    • IPR005466
  • GPR34)
  • GPR87)
  • GPR171, H963)
  • IPR002282

Subfamily A13

  • IPR002230
    • CNR1, CB1R)
    • CNR2, CB2R)
  • IPR004065
    • LPAR1)
    • LPAR2)
    • LPAR3)
  • IPR004061
    • S1PR1)
    • S1PR2)
    • S1PR3)
    • S1PR4)
    • S1PR5)
  • IPR001671
    • Melanocortin 1 receptor (MC1R, MSHR)
    • MC3R)
    • MC4R)
    • MC5R)
    • MC2R), ACTR)
  • GPR3)
  • GPR6)
  • GPR12, GPRC)

Subfamily A14

  • IPR008365
    • PTGDR, PD2R)
    • PTGER1, PE21)
    • PTGER2, PE22)
    • PTGER3, PE23)
    • PTGER4, PE24)
    • PTGFR, PF2R)
    • PTGIR, PI2R)
    • TBXA2R, TA2R)

Subfamily A15

  • IPR004065
    • LPAR4)
    • LPAR5)
    • IPR002188
  • IPR002286
    • P2RY10, P2Y10)
  • IPR003912
    • Coagulation factor II (thrombin) receptor-like 1 (F2RL1, PAR2)
    • F2RL2, PAR3)
    • F2RL3, PAR4)
  • GPR183)
  • Proton-sensing G protein-coupled receptors
    • IPR002276
    • IPR005464
    • IPR005389
    • IPR005388
  • GPR17, GPRH)
  • GPR18, GPRI)
  • GPR20, GPRK)
  • GPR35)
  • GPR55)
  • F2R, THRR)

Subfamily A16

    • RHO, OPSD)
    • OPN1SW, OPSB) (blue-sensitive opsin)
    • OPN1MW, OPSG) (green-sensitive opsin)
    • OPN1LW, OPSR) (red-sensitive opsin)
    • OPN3)
    • OPN4)
    • OPN5, GPR136)
    • RGR)
    • IPR001793

Subfamily A17

  • IPR002231
    • HTR2A, 5H2A)
    • HTR2B, 5H2B)
    • HTR2C, 5H2C)
    • IPR002232
  • IPR002233
    • ADRA1A, A1AA)
    • ADRA1B, A1AB)
    • ADRA1D, A1AD)
    • ADRA2A, A2AA)
    • ADRA2B, A2AB)
    • ADRA2C, A2AC)
    • ADRB1, B1AR)
    • ADRB2, B2AR)
    • ADRB3, B3AR)
  • IPR000929
    • DRD1, DADR)
    • DRD2, D2DR)
    • DRD3, D3DR)
    • DRD4, D4DR)
    • DRD5, DBDR)
  • IPR009132
    • TAAR1, TAR1)
    • TAAR2, GPR58)
    • TAAR3, GPR57)
    • TAAR5, PNR)
    • TAAR6, TAR4)
    • TAAR8, GPR102)
    • TAAR9, TAR3)
  • IPR000503

Subfamily A18

  • IPR000921
  • IPR003980
  • IPR008102
  • IPR001634
    • ADORA1, AA1R)
    • ADORA2A, AA2A)
    • ADORA2B, AA2B)
    • ADORA3, AA3R)
  • IPR000995
    • CHRM1, ACM1)
    • CHRM2, ACM2)
    • CHRM3, ACM3)
    • CHRM4, ACM4)
    • CHRM5, ACM5)
  • GPR21, GPRL)
  • GPR27)
  • GPR45, PSP24)
  • GPR52)
  • GPR61)
  • GPR62)
  • GPR63)
  • GPR78)
  • GPR84)
  • GPR85)
  • GPR88)
  • GPR101)
  • GPR161, RE2)
  • GPR173, SREB3)

Subfamily A19

  • IPR002231
    • HTR1A, 5H1A)
    • HTR1B, 5H1B)
    • HTR1D, 5H1D)
    • HTR1E, 5H1E)
    • HTR1F, 5H1F)
    • IPR001520
    • HTR5A, 5H5A)
    • IPR001069

Unclassified

References

External links

  • This database includes multiple sequence alignments of all GPCR families and sub-families.
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.