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Sb-649,915

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Title: Sb-649,915  
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Subject: 5-HT1A receptor, Elzasonan, RS-56812, MPPF, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
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Sb-649,915

SB-649,915
Systematic (IUPAC) name
6-[(1-[3-(2-methylquinolin-5-yl)oxypropyl]piperidin-4-yl)methyl]-4H-1,4-benzoxazin-3-one
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS number  YesY
ATC code None
PubChem
ChEMBL  N
Chemical data
Formula C26H29N3O3 
Mol. mass 431.526 g/mol
 N   

SB-649,915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects.[1] Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well.[1] This can be attributed to blockade of 5-HT1A and 5-HT1B autoreceptors which inhibit serotonin release.[1]

See also

References

  1. ^ a b c Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. (2007). "SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.". Neuropsychopharmacology. 32 (10): 2163–2172.  
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