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Tolgabide

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Title: Tolgabide  
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Subject: N4-Chloroacetylcytosine arabinoside, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Phaclofen, Gabaculine
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Tolgabide

Tolgabide
Systematic (IUPAC) name
4-{[(Z)-(3-Chloro-5-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)(4-chlorophenyl)methyl]amino}butanamide
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
KEGG
ChEMBL
Chemical data
Formula C18H18Cl2N2O2 
Mol. mass 365.25 g/mol

Tolgabide (SL-81.0142) is a drug which was patented by Synthélabo as an anticonvulsant but was never marketed.[1] It is an analogue of progabide and acts similarly to it as a prodrug of GABA, and therefore as an indirect agonist of the GABA receptors.[1][2]

Synthesis

Tolgabide synthesis: J. P. Kaplan, Synthélabo, DE 3242442  (1983)

See also

References

  1. ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC.  
  2. ^ "The use of common stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances". 2002. 
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