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Vesicular acetylcholine transporter

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Title: Vesicular acetylcholine transporter  
Author: World Heritage Encyclopedia
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Subject: Choline transporter, Neurotransmitter transporter, Excitatory amino acid transporter, Solute carrier family, Equilibrative nucleoside transporter
Collection: Solute Carrier Family
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Vesicular acetylcholine transporter

Solute carrier family 18 (vesicular acetylcholine transporter), member 3
Identifiers
Symbols  ; VACHT
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt n/a
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

The Vesicular acetylcholine transporter (VAChT) is a

External links

  • Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H (Feb 2011). "Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter". The Journal of Biological Chemistry 286 (7): 5836–45.  
  • Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P (Feb 2013). "Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma". Cancer Research 73 (4): 1328–39.  
  • Varoqui H, Erickson JD (Nov 1996). "Active transport of acetylcholine by the human vesicular acetylcholine transporter". The Journal of Biological Chemistry 271 (44): 27229–32.  
  • Harold D, Peirce T, Moskvina V, Myers A, Jones S, Hollingworth P, Moore P, Lovestone S, Powell J, Foy C, Archer N, Walter S, Edmonson A, McIlroy S, Craig D, Passmore PA, Goate A, Hardy J, O'Donovan M, Williams J, Liddell M, Owen MJ, Jones L (Aug 2003). "Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease". Human Genetics 113 (3): 258–67.  
  • Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J (Sep 2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B (6): 762–70.  
  • Schütz B, Chen L, Schäfer MK, Weihe E, Eiden LE (2000). "Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice". Neuroscience 96 (4): 707–22.  
  • Khare P, Mulakaluri A, Parsons SM (Nov 2010). "Search for the acetylcholine and vesamicol binding sites in vesicular acetylcholine transporter: the region around the lumenal end of the transport channel". Journal of Neurochemistry 115 (4): 984–93.  
  • Tayebati SK, El-Assouad D, Ricci A, Amenta F (Nov 2002). "Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes". Journal of Neuroimmunology 132 (1-2): 147–55.  
  • Chireux MA, Le Van Thai A, Weber MJ (Mar 1995). "Human choline acetyltransferase gene: localization of alternative first exons". Journal of Neuroscience Research 40 (4): 427–38.  

Further Reading

  1. ^ Erickson JD, Varoqui H (Dec 2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". FASEB Journal 14 (15): 2450–8.  
  2. ^ Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (Apr 1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proceedings of the National Academy of Sciences of the United States of America 93 (8): 3547–52.  
  3. ^ Waymire, Jack. "Storage of ACh". University of Texas Medical Center. 
  4. ^ Tu Z, Efange SM, Xu J, Li S, Jones LA, Parsons SM, Mach RH (Mar 2009). "Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter". Journal of Medicinal Chemistry 52 (5): 1358–69.  

References

  • (−)-trans-2-Hydroxy-3-(4-(4-[18F]fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2[4]

PET imaging of the VAChT may provide insights into early diagnosis of Alzheimer's disease.

Radiolabeled compounds

VAChT uptake inhibitors

Contents

  • VAChT uptake inhibitors 1
    • Radiolabeled compounds 1.1
  • References 2
  • Further Reading 3
  • External links 4

gene. choline acetyltransferase. This gene is located within the first intron of the vacuolar ATPase Acetylcholine transport utilizes a proton gradient established by a [3]. VAChT is able to transport ACh into vesicles by relying on an exchange between protons that were previously pumped into the vesicle diffusing out. ACh molecules are then carried into the cell by the action of exiting protons. gene (SLC18A3) Solute carrier family 18, member 3 It is encoded by [2][1]

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