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1-Pyrroline-5-carboxylate dehydrogenase

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Title: 1-Pyrroline-5-carboxylate dehydrogenase  
Author: World Heritage Encyclopedia
Language: English
Subject: PYCR1, Formiminotransferase cyclodeaminase, L-threonine dehydrogenase, 3-hydroxyanthranilate oxidase, Proline oxidase
Collection: Ec 1.5.1, Enzymes of Known Structure, Nadh-Dependent Enzymes
Publisher: World Heritage Encyclopedia

1-Pyrroline-5-carboxylate dehydrogenase

1-pyrroline-5-carboxylate dehydrogenase
EC number
CAS number 9054-82-4
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O \rightleftharpoons L-glutamate + NADH + H+

The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40.


  • Adams E and Goldstone A (1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta1-pyrroline-3-hydroxy-5-carboxylate". J. Biol. Chem. 235: 3504–3512.  
  • Strecker HJ (1960). "The interconversion of glutamic acid and proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223. 
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