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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Identifiers
EC number IntEnz BRENDA ExPASy KEGG MetaCyc metabolic pathway
PRIAM PDB structures PDBsum
Gene Ontology EGO

In chemical reaction:

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol \rightleftharpoons 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Hence, this enzyme has one substrate, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and two products, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.

The enzyme is considered a phosphorus-oxygen lyase. The systematic name of this enzyme class is 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include MECDP-synthase, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and CMP-lyase (cyclizing).

Structural studies

As of late 2007, 20 2PMP.

References

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