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5α-Dihydroprogesterone

5α-Dihydroprogesterone
Identifiers
CAS number
PubChem
ChEBI
Jmol-3D images Image 1
Properties
Molecular formula C21H32O2
Molar mass 316.48 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)

5α-Dihydroprogesterone (5α-pregnan-3,20-dione; abbreviated as 5α-DHP) is an endogenous progestogen and neurosteroid that is synthesized from progesterone.[1][2] It is also an intermediate in the synthesis of allopregnanolone from progesterone. 5α-DHP is an agonist of the progesterone receptor, and a positive allosteric modulator of the GABAA receptor.[1][2][3]

See also

References

  1. ^ a b Mellon SH (October 2007). "Neurosteroid regulation of central nervous system development". Pharmacol. Ther. 116 (1): 107–24.  
  2. ^ a b Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E (November 2001). "The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders". Brain Res. Brain Res. Rev. 37 (1-3): 110–5.  
  3. ^ Rupprecht R, Reul JM, Trapp T, et al. (September 1993). "Progesterone receptor-mediated effects of neuroactive steroids". Neuron 11 (3): 523–30.  



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