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5-iai

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Title: 5-iai  
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Subject: HDMP-28, Diclofensine, LR-5182, 3',4'-Methylenedioxy-α-pyrrolidinobutiophenone, Medifoxamine
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5-iai

5-IAI
Systematic (IUPAC) name
5-iodo-2,3-dihydro-1H-inden-2-amine
Clinical data
Pregnancy cat.
  • ?
Legal status
  • Uncontrolled
Routes Oral, Insufflated, Rectal
Identifiers
CAS number  N
ATC code None
PubChem
ChemSpider  YesY
UNII  YesY
Chemical data
Formula C9H10IN 
Mol. mass 259.087 g/mol
 N   

5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]

See also

References

  1. ^ a b Johnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology 200 (1): 9–16.  
  2. ^ a b Nichols DE, Johnson MP, Oberlender R (January 1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology, Biochemistry, and Behavior 38 (1): 135–9.  


Phenylalkylamines
Cyclized phenyl-
alkylamines
Tryptamines
Others


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