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A-372,159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]
Signal transduction, Pharmacology, Cell surface receptor, Hormone, Second messenger system
5-Carboxamidotryptamine, 5-Methoxytryptamine, Metitepine, Lysergic acid diethylamide, Bromocriptine
Acid, Chemistry, Pharmacology, Biochemistry, Temperature
Serotonin, Ergoline, Methysergide, 5-Carboxamidotryptamine, Asenapine