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Title: Adam12  
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Subject: A disintegrin and metalloproteinase, Proteases in angiogenesis
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For the television show, see Adam 12

ADAM metallopeptidase domain 12
ADAM12 Gene
RNA expression pattern

Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.[3]


ADAM12 has been shown to interact with PIK3R1,[4] IGFBP3[5][6] and Actinin, alpha 2.[7]


Further reading

External links

  • The M12.212
  • ADAM12 on the Atlas of Genetics and Oncology

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