Akr1c1

Aldo-keto reductase family 1, member C1
PDB rendering based on 1ihi.
Available structures
PDB Ortholog search: RCSB
Identifiers
1.1.1.112, 1.1.1.149, 1.3.1.20
RNA expression pattern

Aldo-keto reductase family 1 member C1 is an enzyme that in humans is encoded by the AKR1C1 gene.[1][2]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.[2]

References

Further reading

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