World Library  
Flag as Inappropriate
Email this Article

Admixture mapping

Article Id: WHEBN0020141981
Reproduction Date:

Title: Admixture mapping  
Author: World Heritage Encyclopedia
Language: English
Subject: Neanderthal genome project
Publisher: World Heritage Encyclopedia

Admixture mapping

Genetic admixture occurs when individuals from two or more previously separated populations begin interbreeding. Admixture results in the introduction of new genetic lineages into a population. It has been known to slow local adaptation by introducing foreign, unadapted genotypes (known as gene swamping). It also prevents speciation by homogenizing populations.

Genetic admixture often occurs when a geographic barrier separating populations, such as a river or isthmus, is removed or when anthropogenic activities result in movement of populations (for example invasive species).

One example of genetic admixture resulting from the introduction of an invasive species is provided by the Cuban brown anole. Several isolated populations of this species exist in the native range of Cuba. However in the introduced range of Florida, these populations freely interbreed, forming an admixed population.

Another example of a genetic admixture involves a sudden collapse of a natural barrier leading to hybridizations between closely related rival species, such as the grey wolves and the coyotes from the northeastern to the Atlantic regions of North America as well as some parts of the southern US. While wolves and coyotes are closely related and both share a common ancestry, they do not normally interbreed due to the natural hostility between the two species that are known to view each other as competitors. However, between 600 - 900 years ago in the eastern Canada, possible human impacts and persecutions resulting with the decline of the grey wolf populations led to the remnants seeking potential mates in a pre-Columbian coyote population that migrated into the east. The modern day coywolves native to the eastern Canada and the northeastern regions of the US are descendants from the hybrids originating in this genetic admixture.


Admixture mapping is a method of gene mapping that makes use of a population of mixed ancestry (an admixed population) to find the genetic loci that contribute to differences in diseases or other phenotypes found between the different ancestral populations. The method is best applied to populations with recent admixture from two populations that were previously genetically isolated for tens of thousands of years, such as African Americans (admixture of African and European populations). The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest. Genetic markers which differ in frequency between the ancestral populations are needed across the genome.[1]

Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease-causing or phenotype-causing genetic variants between populations. In an admixed population, these causal variants will occur more frequently on chromosomal segments inherited from one or another ancestral population. The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped.[2] These include hypertension, multiple sclerosis, BMI, and prostate cancer in African Americans. By 2010, high-density mapping panels had been constructed for African Americans, Latino/Hispanics, and Uyghurs.

See also


Further reading

  • Kolbe JJ, Glor RE, Schettino LR, Lara AC, Losos AL, Losos JB (2004) Genetic Variation Increases during Biological Invasion by a Cuban Lizard. Nature

431: 171-181

  • Lenormand T (2002). Gene flow and the limits to natural selection. Trends in Ecology and Evolution. 17:183-189
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.