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Title: Alaproclate  
Author: World Heritage Encyclopedia
Language: English
Subject: Zimelidine, Halothane, Methoxetamine, Racemorphan, Methadone
Collection: Chloroarenes, Nmda Receptor Antagonists, Organochlorides, Propionates, Selective Serotonin Reuptake Inhibitors
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
1-(4-Chlorophenyl)-2-methylpropan-2-yl 2-aminopropanoate
Clinical data
Legal status
  • Uncontrolled
Routes of
CAS Registry Number  N
60719-83-7 (hydrochloride)
ATC code N06
PubChem CID:
ChemSpider  Y
Chemical data
Formula C13H18ClNO2
Molecular mass 255.740 g/mol

Alaproclate (GEA-654) is a psychoactive drug and research chemical that was being developed as an antidepressant by the Swedish pharmaceutical company Astra AB (now AstraZeneca) in the 1970s. It acts as a selective serotonin reuptake inhibitor (SSRI), and along with zimelidine and indalpine, was one of the first of its kind. Development was discontinued due to the observation of liver complications in rodent studies. Some studies have found that it acts as a noncompetitive NMDA antagonist, but does not have discriminative stimulus properties similar to phencyclidine.[1][2]

See also


  1. ^ Wilkinson A, Courtney M, Westlind-Danielsson A, Hallnemo G, Akerman KE (December 1994). "Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow". The Journal of Pharmacology and Experimental Therapeutics 271 (3): 1314–9.  
  2. ^ Nicholson KL, Balster RL (November 2003). "Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats". Psychopharmacology (Berlin) 170 (2): 215–24.  

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