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Title: Alpha-enolase  
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Enolase 1, (alpha)
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.

Relationship to Myc-binding protein-1

Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene.[1] Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

Clinical significance

Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy.[2] Single studies have also identified it as an autoantigen associated with severe asthma[3] and a putative target antigen of anti-endothelial cell antibody in Behçet's disease.[4] Reduced expression of the enzyme has been found in the corneal epithelium of people suffering from keratoconus.[5][6]

Interactive pathway map


Alpha-enolase has been shown to interact with TRAPPC2.[7]

See also

External links

  • medscape news report, 25 aug 2006.


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