World Library  
Flag as Inappropriate
Email this Article

Alpha-enolase

Article Id: WHEBN0011189912
Reproduction Date:

Title: Alpha-enolase  
Author: World Heritage Encyclopedia
Language: English
Subject:
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Alpha-enolase

Enolase 1, (alpha)
2PSN.
Available structures
PDB Ortholog search: RCSB
Identifiers
4.2.1.11
RNA expression pattern

Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.

Relationship to Myc-binding protein-1

Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene.[1] Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

Clinical significance

Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy.[2] Single studies have also identified it as an autoantigen associated with severe asthma[3] and a putative target antigen of anti-endothelial cell antibody in Behçet's disease.[4] Reduced expression of the enzyme has been found in the corneal epithelium of people suffering from keratoconus.[5][6]

Interactive pathway map

Interactions

Alpha-enolase has been shown to interact with TRAPPC2.[7]

See also

External links

  • medscape news report, 25 aug 2006.

References


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.