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Title: Astrovirus  
Author: World Heritage Encyclopedia
Language: English
Subject: List of infectious diseases, Astroviridae, Viral diseases, Gastroenterology, Human viruses in water
Collection: Astroviridae, Foodborne Illnesses, Gastroenterology, Viral Diseases
Publisher: World Heritage Encyclopedia


Astrovirus is a type of virus that was first discovered in 1975 using electron microscopes following an outbreak of diarrhoea in humans.[1] In addition to humans, astroviruses have now been isolated from numerous mammalian animal species (and are classified as genus Mammoastrovirus) and from avian species such as ducks, chickens, and turkey poults (classified as genus Aviastrovirus). Astroviruses are 28–35 nm diameter, icosahedral viruses that have a characteristic five- or sixpointed star-like surface structure when viewed by electron microscopy. Along with the Picornaviridae and the Caliciviridae, the Astroviridae comprise a third family of nonenveloped viruses whose genome is composed of plus-sense, single-stranded RNA.[2] Astrovirus has a non-segmented, single stranded, positive sense RNA genome within a non-enveloped icosahedral capsid.[3] Human astroviruses have been shown in numerous studies to be an important cause of gastroenteritis in young children worldwide.[2]


  • Signs and symptoms in humans 1
    • Diagnosis 1.1
  • Epidemiology 2
  • Prevention 3
  • Microbiology 4
    • Taxonomic structure 4.1
    • Virus structure 4.2
    • Genome 4.3
    • Species infected 4.4
  • References 5
  • External links 6

Signs and symptoms in humans

Members of a relatively new virus family, the astroviridae, astroviruses are now recognised as a cause of gastroenteritis in children and adults. The main symptoms are diarrhoea, followed by nausea, vomiting, fever, malaise and abdominal pain. Some research studies have shown that the duration of the symptoms are approximately three to four days. Astrovirus infection is not usually a severe situation and only in some rare cases leads to dehydration. Infected people do not need hospitalization because symptoms reduce by themselves, after a short time.[4]


Electron microscopy, enzyme-immunoassay (ELISA), immunofluorescence, and polymerase chain reaction have all been used for detecting virus particle, antigens or viral nucleic acid in the stools of infected people.[5] A method using real-time RT-PCR, which can detect all human astrovirus genotypes, has been reported.[6]


A study of intestinal disease in the UK, published in 1999, determined incidence as 3.8/1000 patient years in the community (95% CI, range 2.3–6.4), the fourth most common known cause of viral gastroenteritis.[7] Studies in the USA have detected astroviruses in the stools of 2–9% of children presenting symptoms; illness is most frequent in children younger than two years, although outbreaks among adults and the elderly have been reported. Early studies carried out in Glasgow demonstrated that a significant proportion of babies excreting virus particles, 12%, did not exhibit gastrointestinal symptoms; seroprevalence studies carried out in the US have shown that 90% of children have antibody to HastV-1 by age 9, suggesting that (largely asymptomatic) infection is common. There is, as with most viral causes of gastroenteritis, a peak of incidence in the winter.[8]

Humans of all ages are susceptible to astrovirus infection, but children, the elderly, and those that are immunocompromised are most prone. The majority of children have acquired astrovirus antibodies by the age of 5 and, looking at the pattern of disease, it suggests that antibodies provide protection through adult life, until the antibody titre begins to decline later in life.[9][10]

Astroviruses are associated with 5%–9% of cases of gastroenteritis in young children.[11] The occurrence of astrovirus infection varies depending on the season. In temperate climates infection is highest during winter months. This is in contrast to tropical regions where prevalence is highest during the rainy season. This seasonal distribution of infection in temperate climates is rather puzzling. But the seasonal distribution in tropical climates can be explained by the impact of the rain particularly on breakdown of sanitation in developing countries.[8]

The main mode of astrovirus transmission is by contaminated food and water. Young children in childcare backgrounds or adults in military barracks are most likely to develop the disease.


Inactivated vaccines are in use for certain strains of Chicken Astrovirus (CastV).

There are no anti-viral treatment against infections but personal hygiene can reduce the incidence of the illness.


Taxonomic structure

The family Astroviridae contains two genera: Mamastroviruses which infect mammals and Avastroviruses which infect birds. In each genus, there are species of astroviruses, each named after the host in which they replicate. The astroviruses are further subclassified within each species into serotypes.[12]

There are at least three genotypes of bovine astroviruses.[13] These appear to be related to the Capreolus capreolus astrovirus.

Virus structure

Astroviruses have a star-like appearance with five or six points. Their name is derived from the Greek word "astron" meaning star. They are non-enveloped RNA viruses with cubic capsids, approximately 28–35 nm in diameter.[14]


Astroviruses have a genome composed of a single strand of positive sense RNA. The strand has a poly A tail at the 3' end, but no 5' cap. With the exclusion of polyadenylation at the 3' end, the genome is between 6.8–7.9 kb long.

The genome is arranged into three open reading frames (ORFs), with an overlap of approximately 70 nucleotides between ORF1a and ORF1b. The remaining ORF is known as ORF2.[15] ORF2 encode the structural proteins, which are -at least- VP26, VP29 and VP32, the most antigenic and immunogenic of these being VP26. This protein is probably involved in the first steps of viral infection, being a key factor in the biological cycle of astroviruses.[16]

The mutation rate has been estimated to be 3.7×10−3 nucleotide substitutions per site per year with the synonymous changes rate of 2.8×10−3 nucleotide substitutions per site per year.[17]

Species infected

In addition to humans, goats, cattle, pigs, wild boar, sheep, roe deer, bats, sea lions, rats, and mice are known to be infected with these viruses.[18][19][20]


  1. ^ Madeley CR, Cosgrove BP (1975). "Letter: 28 nm particles in faeces in infantile gastroenteritis". Lancet 2 (7932): 451–2.  
  2. ^ a b Brown DW, Gunning KB, Henry DM, et al. (January 2008). "A DNA Oligonucleotide Microarray for Detecting Human Astrovirus Serotypes". Journal of Virological Methods 147 (1): 86–92.  
  3. ^ Matsui SM, Kiang D, Ginzton N, Chew T, Geigenmüller-Gnirke U (2001). "Molecular biology of astroviruses: selected highlights". Novartis Found. Symp. Novartis Foundation Symposia 238: 219–33; discussion 233–6.  
  4. ^ Madeley CR (1988). "Virus diarrhoea in hospital". J. Hosp. Infect. 12 (3): 145–9.  
  5. ^ Guix S, Bosch A, Pintó RM (2005). "Human astrovirus diagnosis and typing: current and future prospects". Lett. Appl. Microbiol. 41 (2): 103–5.  
  6. ^ Royuela E, Negredo A, Sánchez-Fauquier A (April 2006). "Development of a one step real-time RT-PCR method for sensitive detection of human astrovirus". Journal of Virological Methods 133 (1): 14–9.  
  7. ^ "Infectious diseases in England and Wales: January to March 1999". Commun. Dis. Rep. CDR Suppl. 9 (4): S1–20. 1999.  
  8. ^ a b Glass RI, Noel J, Mitchell D, et al. (1996). "The changing epidemiology of astrovirus-associated gastroenteritis: a review". Arch. Virol. Suppl. 12: 287–300.  
  9. ^ Koopmans MP, Bijen MH, Monroe SS, Vinjé J (1998). "Age-Stratified Seroprevalence of Neutralizing Antibodies to Astrovirus Types 1 to 7 in Humans in The Netherlands". Clin. Diagn. Lab. Immunol. 5 (1): 33–7.  
  10. ^ Midthun K, Greenberg HB, Kurtz JB, Gary GW, Lin FY, Kapikian AZ (1993). "Characterization and seroepidemiology of a type 5 astrovirus associated with an outbreak of gastroenteritis in Marin County, California". J. Clin. Microbiol. 31 (4): 955–62.  
  11. ^ Monroe SS, Holmes JL, Belliot GM (2001). "Molecular epidemiology of human astroviruses". Novartis Foundation Symposium. Novartis Foundation Symposia 238: 237–45; discussion 245–9.  
  12. ^ Lukashov VV, Goudsmit J (2002). "Evolutionary relationships among Astroviridae". J. Gen. Virol. 83 (Pt 6): 1397–405.  
  13. ^ Tse H, Chan WM, Tsoi HW, Fan RY, Lau CC, Lau SK, Woo PC, Yuen KY. (2011) Re-discovery and genomic characterization of bovine astroviruses. J Gen Virol.
  14. ^ Krishna NK (2005). "Identification of Structural Domains Involved in Astrovirus Capsid Biology". Viral Immunol. 18 (1): 17–26.  
  15. ^ Willcocks MM, Brown TD, Madeley CR, Carter MJ (1994). "The complete sequence of a human astrovirus". J. Gen. Virol. 75 (7): 1785–8.  
  16. ^ Royuela E. (2010). "Molecular cloning, expression and first antigenic characterization of human astrovirus VP26 structural protein and a C-terminal deleted form.". Comp Immunol Microbiol Infect Dis. 33(3) (277): 1–14.  
  17. ^ Babkin IV, Tikunov AY, Zhirakovskaia EV, Netesov SV, Tikunova NV (2012) High evolutionary rate of human astrovirus. Infect Genet Evol
  18. ^ Virus taxonomy: classification and nomenclature of viruses: Ninth Report of the International Committee on Taxonomy of Viruses. (2012) Ed: King, A.M.Q., Adams, M.J., Carstens, E.B. and Lefkowitz, E.J. San Diego: Elsevier.
  19. ^ Phan TG, Kapusinszky B, Wang C, Rose RK, Lipton HL, et al. (2011) "The Fecal Viral Flora of Wild Rodents". PLoS Pathog 7(9) e1002218. doi:10.1371/journal.ppat.1002218
  20. ^ Ng TFF, Kondov NO, Hayashimoto N, Uchida R, Cha Y, et al. (2013) "Identification of an Astrovirus Commonly Infecting Laboratory Mice in the US and Japan". PLoS ONE 8(6) e66937.doi:10.1371/journal.pone.0066937

External links

  • : AstroviridaeViralzone
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