World Library  
Flag as Inappropriate
Email this Article

Azastene

Article Id: WHEBN0041568139
Reproduction Date:

Title: Azastene  
Author: World Heritage Encyclopedia
Language: English
Subject: Cyanoketone, Cyproterone acetate, Metyrapone, 22R-Hydroxycholesterol, 20α,22R-Dihydroxycholesterol
Collection: Isoxazoles, Steroids
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Azastene

Azastene
Names
Other names
Win-17625
Identifiers
ChEMBL
ChemSpider
Jmol-3D images Image
PubChem
Properties
C23H33NO2
Molar mass 355.52 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Azastene is a chemical that modulates 3β-hydroxysteroid dehydrogenase activity.[1]

Synthesis

Azastene synthesis:[2]

One synthesis of this compound involves initial alkylation of methyl testosterone by means of strong base and methyl iodide to afford the 4,4-dimethyl derivative. Formylation with alkoxide and methyl formate leads to the 2-hydroxymethyl derivative. Reaction of this last with hydroxylamine leads to formation of an isoxazole ring. There is then obtained azastene.

References

  1. ^
  2. ^ Gordon O. Potts, Sterling Drug Inc. U.S. Patent 3,966,926 (1976).
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.