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B-cell prolymphocytic leukemia

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Title: B-cell prolymphocytic leukemia  
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Subject: Leukemia, Lymphoma, Hairy cell leukemia, International Classification of Diseases for Oncology, Lymphoid leukemia
Publisher: World Heritage Encyclopedia

B-cell prolymphocytic leukemia

B-cell prolymphocytic leukemia
Classification and external resources
ICD-O: MeSH D054403

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

It can involve deletions from chromosome 11 and chromosome 13.[1]

It has been suggested that some cases may represent a variant of mantle cell lymphoma.[2]

It has a relatively poor prognosis.[3]


A case has been described as CD20+, CD22+, and CD5-.[4]

It can also be CD5+.[5]

Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.[6]


Splenic irradiation has been used in the treatment.[7]



pt:Leucemia prolinfocítica

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