Bafilomycin-A1

Bafilomycin A1[1]
Identifiers
CAS number 88899-55-2 N
PubChem 6436223
ChemSpider 10251049 YesY
DrugBank DB06733
Jmol-3D images Image 2
Properties
Molecular formula C35H58O9
Molar mass 622.83 g/mol
Appearance Yellow powder
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase.

The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Bafilomycin has antibacterial, antifungal, antineoplastic, immunosuppressive activities.In addition, bafilomycin A1 has antimalarial activity [2] It has been shown to decrease multi-drug resistance.

Bafilomycin B1 has been mentioned as a potential antiosteoporotic agent in treating bone lytic diseases.

References

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