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Binospirone

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Title: Binospirone  
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Subject: 5-HT1A receptor, RS-56812, MPPF, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide, BRL-54443
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Binospirone

Binospirone
Systematic (IUPAC) name
8-[2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione
Clinical data
Legal status
?
Identifiers
CAS number
ATC code None
PubChem
ChemSpider
UNII  YesY
ChEMBL
Chemical data
Formula C20H26N2O4 
Mol. mass 358.431 g/mol
 YesY   

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.[1] It has anxiolytic effects.[2]

Synthesis

Binospirone synthesis: EP0236930 

See also

References

  1. ^ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology, Biochemistry, and Behavior 68 (4): 647–60.  
  2. ^ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology 99 (2): 343–9.  
5-HT1A agonists
GABAAR PAMs
α2δ VDCC blockers
Antidepressants
Sympatholytics
Others

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