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Cd80

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Title: Cd80  
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Cd80

CD80 molecule

Rendering of
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4[1][2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

See also

References

  1. ^ Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7.  
  2. ^ Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses".  

Further reading



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