World Library  
Flag as Inappropriate
Email this Article

Cgp-37849

Article Id: WHEBN0018601698
Reproduction Date:

Title: Cgp-37849  
Author: World Heritage Encyclopedia
Language: English
Subject: NMDA receptor antagonists, MMPIP, LY-307,452, LY-344,545, PCCG-4
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Cgp-37849

CGP-37849
Systematic (IUPAC) name
(E,2R)-2-amino-4-methyl-5-phosphonopent-3-enoic acid
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem
ChemSpider  N
ChEMBL  N
Synonyms CGP-37849, CGP-40116
Chemical data
Formula C6H12NO5P 
Mol. mass 209.137 g/mol
 N   

CGP-37849 is a competitive antagonist at the NMDA receptor.[1] It is a potent, orally active anticonvulsant in animal models,[2] and was researched for the treatment of epilepsy.[3] It also has neuroprotective activity[4] and shows antidepressant[5][6] and anxiolytic effects.[7][8]


References

  1. ^ Fagg GE, Olpe HR, Pozza MF, Baud J, Steinmann M, Schmutz M, Portet C, Baumann P, Thedinga K, Bittiger H, et al. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. British Journal of Pharmacology. 1990 Apr;99(4):791-7. PMID 1972895
  2. ^ Schmutz M, Portet C, Jeker A, Klebs K, Vassout A, Allgeier H, Heckendorn R, Fagg GE, Olpe HR, van Riezen H. The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. Naunyn-Schmiedebergs Archives of Pharmacology. 1990 Jul;342(1):61-6. PMID 1976233
  3. ^ Fujikawa DG, Daniels AH, Kim JS. The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. Epilepsy Research. 1994 Mar;17(3):207-19. PMID 7912191
  4. ^ Gutnikov SA, Gaffan D. Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys. Journal of Neuroscience. 1996 Jun 15;16(12):4041-5. PMID 8656297
  5. ^ Maj J, Klimek V, Gołembiowska K, Rogóz Z, Skuza G. Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity. Polish Journal of Pharmacology. 1993 Sep-Dec;45(5-6):455-66. PMID 7912134
  6. ^ Papp M, Moryl E. Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression. European Journal of Pharmacology. 1994 Sep 22;263(1-2):1-7. PMID 7821340
  7. ^ Jessa M, Nazar M, Bidzinski A, Plaznik A. The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety. European Neuropsychopharmacology. 1996 Mar;6(1):55-61. PMID 8866939
  8. ^ Przegaliński E, Tatarczyńska E, Chojnacka-Wójcik E. The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. Neuropharmacology. 2000 Jul 24;39(10):1858-64. PMID 10884566
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.