Chd2

Chromodomain helicase DNA binding protein 2
Identifiers
3.6.4.12
RNA expression pattern

Chromodomain-helicase-DNA-binding protein 2 is an enzyme that in humans is encoded by the CHD2 gene.[1][2]

Function

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

Mutations in this gene have been found associated to cases of epileptic encephalopathies. (doi: 10.1038/ng.2646)

References

Further reading

External links

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