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Cannabigerol

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Cannabigerol

Cannabigerol
Systematic (IUPAC) name
2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol
Clinical data
Legal status
?
Identifiers
CAS number  N
ATC code None
PubChem
ChemSpider  YesY
ChEMBL  YesY
Chemical data
Formula C21H32O2 
Mol. mass 316.48 g/mol
 N   

Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the Cannabis genus of plants. Cannabigerol is found in higher concentrations in hemp rather than in varieties of Cannabis cultivated for high THC content and their corresponding psychoactive properties.

Cannabigerol has been found to act as a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist.[1] It also binds to the CB2 receptor, but whether it acts as an agonist or antagonist at this site is unknown.[1]

Cannabigerol has been shown to relieve interocular pressure, which may be of benefit in the treatment of glaucoma.[2][3] It can also be used to treat inflammatory bowel disease. [4]

It has two E/Z isomers. It is not scheduled by Convention on Psychotropic Substances.

See also

References

  1. ^ a b Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). "Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist".  
  2. ^ Colasanti, B. (1990). "A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol". Journal of ocular pharmacology 6 (4): 259–269.  
  3. ^ Colasanti, B.; Craig, C.; Allara, R. (1984). "Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol". Experimental eye research 39 (3): 251–259.  
  4. ^ http://www.ncbi.nlm.nih.gov/pubmed/23415610
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