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Carboxypeptidase B

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Title: Carboxypeptidase B  
Author: World Heritage Encyclopedia
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Subject: Carboxypeptidase A, Proteases, Enkephalinase, Carboxypeptidase A6, Glutamate carboxypeptidase II
Collection: Ec 3.4.17, Metabolism
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Carboxypeptidase B

carboxypeptidase B1 (tissue)
Identifiers
Symbol CPB1
Entrez 1360
HUGO 2299
OMIM 114852
RefSeq NM_001871
UniProt P15086
Other data
EC number 3.4.17.2
Locus Chr. 3 q24
carboxypeptidase B2 (plasma)
Identifiers
Symbol CPB2
Entrez 1361
HUGO 2300
OMIM 603101
RefSeq NM_016413
UniProt Q96IY4
Other data
Locus Chr. 13 q14.11
carboxypeptidase B
Identifiers
EC number 3.4.17.2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.[1][2][3][4] This serum enzyme is also responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.

References

  1. ^ Folk, J.E. (1970). "Carboxypeptidase B (porcine pancreas)". Methods Enzymol. 19: 504–508.  
  2. ^ Brodrick, J.W., Geokas, M.C. and Largman, C. (1976). "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion". Biochim. Biophys. Acta 452: 468–481.  
  3. ^ Butterworth, J. and Duncan, J.J. (1979). "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis". Clin. Chim. Acta 97: 39–43.  
  4. ^ Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D. (1982). "Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?". Life Sci. 31: 1793–1796.  

External links

  • The MEROPS online database for peptidases and their inhibitors: M14.003
  • Carboxypeptidase B at the US National Library of Medicine Medical Subject Headings (MeSH)
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