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Cathine

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Title: Cathine  
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Subject: Cathinone, Fenbutrazate, Amfecloral, Etilamfetamine, Buphedrone
Collection: Alcohols, Amphetamine Alkaloids, Decongestants, Euphoriants, Norepinephrine-Dopamine Releasing Agents
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Cathine

Cathine
Systematic (IUPAC) name
(1S,2S)-2-amino-1-phenylpropan-1-ol
Clinical data
Legal status
Routes of
administration
Oral
Pharmacokinetic data
Biological half-life 1.8-8.6 h[1]
Identifiers
CAS Registry Number  Y
ATC code A08
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
ChEMBL
Chemical data
Formula C9H13NO
Molecular mass 151.206 g/mol
 Y   

Cathine, also known as d-norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which acts as a stimulant. Along with cathinone, it is found naturally in Catha edulis (khat), and contributes to its overall effects.[2] It has approximately 10-14% the potency of amphetamine.[2]

Contents

  • Pharmacology 1
  • Chemistry 2
  • Regulation 3
  • See also 4
  • References 5

Pharmacology

Like amphetamines, cathinone, and ephedrine, cathine acts as a releasing agent of norepinephrine and epinephrine, or as a norepinephrine releasing agent (NRA).[2] It also acts as a dopamine releasing agent (DRA) to a lesser extent.[2]

Chemistry

Cathine is one of the optical isomers of phenylpropanolamine (PPA).

Regulation

The World Anti-Doping Agency's list of prohibited substances (used for the Olympic Games among other athletic events) bars cathine in concentrations of over 5 micrograms per milliliter in urine. Cathine is a Schedule III drug under the Convention on Psychotropic Substances.[3] In the United States, it is classified as a Schedule IV controlled substance.

Cathine is found in shrub Catha edulis.

In Hong Kong, cathine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Unlawful possession is punishable by severe fines and imprisonment.

See also

References

  1. ^ Toennes SW, Harder S, Schramm M, Niess C, Kauert GF (2003). "Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves". Br J Clin Pharmacol 56 (1): 125–130.  
  2. ^ a b c d Hoffman, R; Al'Absi, M (December 2010). "Khat use and neurobehavioral functions: suggestions for future studies." (PDF). Journal of Ethnopharmacology 132 (3): 554–63.  
  3. ^ "List of psychotropic substances under international control" (PDF). International Narcotics Control Board. Archived from the original (PDF) on 2012-08-31. 
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