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CAS number  YesY
ChemSpider  YesY
ATC code A04
Jmol-3D images Image 1
Molecular formula C4H7Cl3O
Molar mass 177.46 g mol−1
Appearance White solid
Odor Menthol
Melting point 95–99 °C (203–210 °F; 368–372 K)
Boiling point 167 °C (333 °F; 440 K)
Solubility in water Slightly soluble
Solubility in acetone Soluble
Main hazards Xn
NFPA 704
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. In pure state it's a white, menthol like odor, volatile solid.


  • Chemical synthesis 1
  • Toxicity 2
  • References 3
  • External links 4

Chemical synthesis

Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide.


In a pure state, the substance is toxic by ingestion (damage to the liver) in excessive doses. If the substance touches the skin it may generate irritation and also it may cause some serious damage to the eye if there's contact.[1]


  1. ^ MSDS

External links

  • Chlorobutanol MSDS
  • A04

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