Cyclin-dependent kinase 8

Available structures

PDB

Ortholog search: PDBe, RCSB

List of PDB id codes
, , , , , , , , ,

Identifiers

Symbols

; K35

External IDs

ChEMBL: GeneCards:

EC number

Gene ontology
Molecular function	• • • • •
Cellular component	• • •
Biological process	• • • • • • • •
Sources: Amigo / QuickGO

RNA expression pattern

Orthologs

Species

Human

Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.^[1]^[2] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.^[2] See also Protein kinase domain to view the more general properties of kinases.

1 Interactions
2 References
3 Further reading
4 External links

Interactions

Cyclin-dependent kinase 8 has been shown to interact with MED16,^[3]^[4] MED26,^[5] MED17,^[3]^[4] MED14,^[3]^[6] CREB binding protein,^[7] MED1,^[3]^[4] MED6,^[3]^[4]^[6]^[8] MED24,^[3]^[4] CCNC,^[1]^[4]^[6]^[7]^[9] POLR2A,^[7] MED21,^[3]^[4]^[7]^[10] SMARCB1,^[7] MED12^[3]^[4] and CRSP3.^[4]^[6]

References

^ ^a ^b Tassan JP, Jaquenoud M, Leopold P, Schultz SJ, Nigg EA (Oct 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc Natl Acad Sci U S A 92 (19): 8871–5.

^ a ^b "Entrez Gene: CDK8 cyclin-dependent kinase 8".
^ ^a ^b ^c ^d ^e ^f ^g ^h Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–70.

^ a ^b ^c ^d ^e ^f ^g ^h ⁱ Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro".

^ Sato, Shigeo; Tomomori-Sato Chieri, Parmely Tari J, Florens Laurence, Zybailov Boris, Swanson Selene K, Banks Charles A S, Jin Jingji, Cai Yong, Washburn Michael P, Conaway Joan Weliky, Conaway Ronald C (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell (United States) 14 (5): 685–91.

^ a ^b ^c ^d Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. (United States) 21 (14): 4604–13.

^ a ^b ^c ^d ^e Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63.

^ Yang, Fajun; DeBeaumont Rosalie; Zhou Sharleen; Näär Anders M (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator".

^ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell (UNITED STATES) 89 (3): 357–64.

^ Suñé, C; Hayashi T; Liu Y; Lane W S; Young R A; Garcia-Blanco M A (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6029–39.

Further reading

Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30.

Rickert P, Seghezzi W, Shanahan F, et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene 12 (12): 2631–40.

Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23.

Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10.

Neish AS, Anderson SF, Schlegel BP, et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme". Nucleic Acids Res. 26 (3): 847–53.

Cho H, Orphanides G, Sun X, et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63.

Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–22.

Rickert P, Corden JL, Lees E (1999). "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases". Oncogene 18 (4): 1093–102.

Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108.

Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–70.

Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–8.

Akoulitchev S, Chuikov S, Reinberg D (2000). "TFIIH is negatively regulated by cdk8-containing mediator complexes". Nature 407 (6800): 102–6.

Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences". J. Biol. Chem. 276 (14): 10913–20.

Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. 21 (14): 4604–13.

Di Pietro C, Rapisarda A, Bonaiuto C, et al. (2001). "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7". Somat. Cell Mol. Genet. 25 (3): 185–9.

Vogel L, Baratte B, Détivaud L, et al. (2002). "Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein". Biochim. Biophys. Acta 1589 (2): 219–31.

Crowley TE, Kaine EM, Yoshida M, et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.

Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7.

External links

CDK8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

CDK8 human gene location in the UCSC Genome Browser.

CDK8 human gene details in the UCSC Genome Browser.

Cell cycle proteins

Cyclin

A (A1, A2)

B (B1, B2, B3)

D (D1, D2, D3)

E (E1, E2)

CDK

1

2

3

4

5

6

7

8

9

10

CDK-activating kinase

CDK inhibitor

INK4a/ARF (p14arf/p16, p15, p18, p19)

cip/kip (p21, p27, p57)

P53 p63 p73 family

p53

p63

p73

Other

Cdc2

Cdc25

Cdc42

Cellular apoptosis susceptibility protein

E2F

Maturation promoting factor

Wee

Cullin (CUL7)

Phases and
checkpoints

Interphase

G₁ phase

S phase

G₂ phase

M phase

Mitosis (Preprophase

Prophase

Prometaphase

Metaphase

Anaphase

Telophase)

Cytokinesis

Cell cycle checkpoints

Restriction point

Spindle checkpoint

Postreplication checkpoint

Other cellular phases

Apoptosis

G₀ phase

Meiosis

'' : dna

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stru

Categories

Human proteins

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Cell cycle

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Cyclin-dependent kinase 8