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Cyclin E1

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Title: Cyclin E1  
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Subject: Postreplication checkpoint, Cellular apoptosis susceptibility protein, Cyclin B2, CDKN2D, CDKN2C
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Cyclin E1

Cyclin E1

PDB rendering based on 1w98.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CCNE
External IDs ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.[1] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.[2]

See also

Interactions

Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2,[3][4] Cdk1,[3][5] CDC25A,[3][6] Cyclin-dependent kinase 2,[3][5][7][8][9][10] SMARCA4,[3][11] CDKN1B,[3][9] HERC5,[12] CUL3[13] and P21.[7]

References

  1. ^ Lew DJ, Dulic V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell 66 (6): 1197–206.  
  2. ^ "Entrez Gene: CCNE1 cyclin E1". 
  3. ^ a b c d e f Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9.  
  4. ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (December 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77.  
  5. ^ a b Koff, A; Giordano A; Desai D; Yamashita K; Harper J W; Elledge S; Nishimoto T; Morgan D O; Franza B R; Roberts J M (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle".  
  6. ^ Xu, X; Burke S P (March 1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. (UNITED STATES) 271 (9): 5118–24.  
  7. ^ a b McKenzie, Pamela P; Danks Mary K; Kriwacki Richard W; Harris Linda C (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest". Cancer Res. (United States) 63 (13): 3840–4.  
  8. ^ Mayer, Christine; Zhao Jian; Yuan Xuejun; Grummt Ingrid (February 2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. (United States) 18 (4): 423–34.  
  9. ^ a b Connor, Michael K; Kotchetkov Rouslan; Cariou Sandrine; Resch Ansgar; Lupetti Rafaella; Beniston Richard G; Melchior Frauke; Hengst Ludger; Slingerland Joyce M (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell (United States) 14 (1): 201–13.  
  10. ^ Boudrez, A; Beullens M; Groenen P; Van Eynde A; Vulsteke V; Jagiello I; Murray M; Krainer A R; Stalmans W; Bollen M (August 2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. (UNITED STATES) 275 (33): 25411–7.  
  11. ^ Wong, A K; Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland A M, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian S V, Teng D H, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines". Cancer Res. (UNITED STATES) 60 (21): 6171–7.  
  12. ^ Mitsui, K; Nakanishi M; Ohtsuka S; Norwood T H; Okabayashi K; Miyamoto C; Tanaka K; Yoshimura A; Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem. Biophys. Res. Commun. (UNITED STATES) 266 (1): 115–22.  
  13. ^ Singer, J D; Gurian-West M; Clurman B; Roberts J M (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes Dev. (UNITED STATES) 13 (18): 2375–87.  

Further reading


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