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David H. Koch Institute for Integrative Cancer Research

David H. Koch Institute for Integrative Cancer Research
Logo of the David H. Koch Institute
Established October 9, 2007
Research type Basic (non-clinical) research
Budget $24.5 million[1]
Field of research
Cancer research
Director Tyler Jacks
Faculty 25[2]
Staff 500[2]
Address 77 Massachusetts Ave.
Building 76
Location Cambridge, Massachusetts
Campus 180,000 square feet (17,000 m2)
Affiliations National Cancer Institute
Operating agency
Massachusetts Institute of Technology
David H. Koch Institute for Integrative Cancer Research

The David H. Koch Institute for Integrative Cancer Research ( ; also referred to as the Koch Institute, KI, or CCR/KI) is a cancer research center affiliated with the Massachusetts Institute of Technology (MIT) located in Cambridge, Massachusetts, United States. The Institute is one of eight National Cancer Institute-designated basic research centers in the United States.[3][4]

The Institute was launched in October 2007 with a $100 million grant from David H. Koch and the 180,000 square feet (17,000 m2) research facility opened in December 2010, replacing the MIT Center for Cancer Research (CCR).[5][6] The Institute is affiliated with 25 MIT faculty members in both the Schools of Engineering and Science.[7]


  • History 1
  • Mission 2
  • Affiliates 3
  • Building 4
  • Activity since 2007 5
  • References 6
  • External links 7


In 1974, the Center for Cancer Research was founded by 1969

  • Official homepage
  • Interview with Tyler Jacks

External links

  1. ^ a b c d e "Annual Reports to the President, 2007–2008: David H. Koch Institute for Integrative Cancer Research". Office of the President, Massachusetts Institute of Technology. Retrieved 2009-08-08. 
  2. ^ a b c "People". The Koch Institute, Massachusetts Institute of Technology. Retrieved 2009-09-09. 
  3. ^ "Cancer Centers Program - MIT Center for Cancer Research". National Cancer Institute. Retrieved 2009-09-08. 
  4. ^ a b c d "The Koch Institute - Frequently Asked Questions". The Koch Institute, Massachusetts Institute of Technology. Retrieved 2009-09-08. 
  5. ^ Trafton, Anne (October 9, 2007). "David H. Koch gives $100 million to MIT for cancer research". MIT News Office. 
  6. ^ a b Strout, Erin (October 10, 2007). "MIT Receives $100-Million Gift for Cancer-Research Center". The Chronicle of Higher Education. 
  7. ^ a b c Trafton, Anne (March 8, 2008). "MIT breaks ground for Koch institute". MIT News Office. 
  8. ^ "Annual Reports to the President, 1994–1995: Center for Cancer Research". Office of the President, Massachusetts Institute of Technology. Retrieved 2009-08-08. 
  9. ^ a b "Annual Reports to the President, 2006–2007: Center for Cancer Research". Office of the President, Massachusetts Institute of Technology. Retrieved 2009-08-08. 
  10. ^ a b Thomson, Elizabeth (June 26, 2006). "Cancer Center highlights past, present research". MIT News Office. 
  11. ^ Richards, Patti (November 14, 2006). "MIT receives major grant from the Ludwig Fund to tackle metastasis". MIT News Office. 
  12. ^ a b Dembner, Alice (October 10, 2007). "MIT gets $100m for cancer center". Boston Globe. 
  13. ^ Halber, Deborah (February 10, 1999). "David Koch '62 donates $25m for cancer research". MIT News Office. 
  14. ^ "Lecture marks Koch Building naming cancer-research gift". MIT News Office. September 29, 1999. 
  15. ^ "Research". The David H. Koch Institute for Integrative Cancer Research at MIT. Retrieved 20 April 2011. 
  16. ^ Video of Topping-Off Ceremony "Highlights of Koch Institute Topping-Off Ceremony". MIT News Office. February 20, 2009. 
  17. ^ "While you were out". MIT News Office. September 2, 2009. 
  18. ^ Brobbey, Valery (February 26, 2008). "Cancer Building Groundbreaking Scheduled". The Tech. 
  19. ^ Briggs, Helen (April 7, 2011). "Gene clue to how cancer spreads". BBC. Retrieved 21 April 2011. 


In 2011, scientists at the Institute pinpointed a genetic change that makes lung cancer more likely to spread around the body and may help scientists develop new drugs to fight secondary tumors.[19]

The KI remains funded by a NCI center grant as well as 110 fully funded projects. Research volume in 2007–2008 totaled $24.5 million.[1] Notable grants include Mouse Models of Cancer Consortium, Integrative Cancer Biology Program, and the Centers for Excellence in Nanotechnology and Cancer.[4]

Activity since 2007

The building was designed by Cambridge-based architecture firm Ellenzweig, which designed several other buildings on the MIT campus.[18] Designed to encourage interaction and collaboration, the building employs both dedicated lab space as well as common areas, and features a ground-floor gallery exhibiting art and technical displays related to biomedical research.[1] The building includes facilities for bioinformatics and computing, genomics, proteomics and flow cytometry, large-scale cell and animal facilities for genetic engineering and testing, advanced imaging equipment, and nanomaterials characterization labs.[7]

The 180,000 square feet (17,000 m2) research facility is located on the corner of Main Street and Ames Street near Kendall Square in Cambridge, Massachusetts. The building is located opposite the Whitehead Institute and Broad Institute and near the biology and chemical engineering buildings on the north-eastern end of MIT's campus. MIT broke ground on Building 76 in March 2008,[7] a topping-off ceremony was held in February 2009,[16] and the building was dedicated on March 4, 2011.[17]


Notable faculty members affiliated with the Koch Institute include:[2]

The Koch Institute is home to faculty members from various departments, including Biology, Chemistry, Mechanical Engineering, and Biological Engineering; more than 40 laboratories and 500 researchers across the campus.[1] Koch Institute faculty teach classes at MIT, as well as train graduate and undergraduate students as well as postdoctoral fellows. The Koch Institute is affiliated with two current Nobel Laureates (Horvitz and Sharp), fifteen members of the National Academy of Sciences, one member of the National Academy of Engineering, six National Medal of Science laureates, and five Howard Hughes Medical Institute investigators, and one MacArthur Foundation Fellowship recipient.[4]


The Koch Institute has identified five areas of research that it believes are critical for controlling cancer: Developing nanotechnology-based cancer therapeutics, creating novel devices for cancer detection and monitoring, exploring the molecular and cellular basis of metastasis, advancing personalized medicine through analysis of cancer pathways and drug resistance, engineering the immune system to fight cancer.[15]

The Koch Institute emphasizes basic research into how cancer is caused, progresses, and responds to treatment. Unlike many other NCI Cancer Centers, it will not provide medical care or conduct clinical research but it has partnered with oncology centers such as the Massachusetts General Hospital's Cancer Center.[4] The Institute combines the existing faculty of the CCR with an equivalent number of engineering faculty to promote interdisciplinary approaches to diagnosing, monitoring, and treating cancer.[1]


In 2006, President Susan Hockfield announced plans for a new CCR center to support and expand cancer research performed by biologists and engineers.[9][10] A $20 million grant was made by the Ludwig Fund in November 2007 to support a Center for Molecular Oncology to be administered by the CCR.[11] In 2007, MIT announced it had received a $100 million gift from David H. Koch, the executive vice president of the oil conglomerate Koch Industries. Koch graduated from MIT with bachelors and masters degrees in chemical engineering and served on the university's board of directors since 1988. Koch survived a prostate cancer diagnosis in 1992,[12] previously donated $25 million over ten years to MIT to support cancer research,[13] and is the namesake of the university's biology building.[14] Half of the gift will go towards construction of the estimated $240–$280 million facility and half will pay for research, on the condition that MIT builds the center even if fund raising falls short.[6][12]

[10] (2002).H. Robert Horvitz (1993), and Phillip Sharp (1987), Susumu Tonegawa (1975), David Baltimore, and roles of various cellular proteins. The CCR produced four Nobel Laureates: T lymphocytes, immunology of oncogenes, and foundation support. The CCR research groups were successful in identifying Howard Hughes Medical Institute, National Institutes of Health Financial support for the CCR primarily came from Center Core grant from the National Canter Institute as well as research project grants from the [9]

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