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Docosahexaenoic acid

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Title: Docosahexaenoic acid  
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Docosahexaenoic acid

Docosahexaenoic acid
Names
IUPAC name
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid; Doconexent
Other names
cervonic acid, DHA
Identifiers
 Y
ChEBI  Y
ChEMBL  Y
ChemSpider  Y
Jmol-3D images Image
PubChem
UNII  Y
Properties
C22H32O2
Molar mass 328.488 g/mol
Density 0.943 g/cm3
Melting point −44 °C (−47 °F; 229 K)
Boiling point 446.7 °C (836.1 °F; 719.8 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 Y  (: Y/N?)

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, sperm, testicles and retina. It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk or fish oil.[1] DHA's structure is a carboxylic acid (-oic acid) with a 22-carbon chain (docosa- is Greek for 22) and six (hexa-) cis double bonds (-en-);[2] with the first double bond located at the third carbon from the omega end.[3] Its trivial name is cervonic acid, its systematic name is all-cis-docosa-4,7,10,13,16,19-hexa-enoic acid, and its shorthand name is 22:6(n-3) in the nomenclature of fatty acids.

Cold-water Crypthecodinium cohnii and another of the genus Schizochytrium.[4] DHA manufactured using microalgae is vegetarian.[5]

Some animals with access to [9] DHA is a major fatty acid in sperm and brain phospholipids and in the retina. A low level of DHA is spotted in patients with retinitis pigmentosa. Below-normal levels of DHA have also been associated with Alzheimer's disease. Dietary DHA may reduce the level of blood triglycerides in humans.[10] Nonetheless, studies of fish oil supplements, which contain DHA, have failed to support claims of preventing heart attacks or strokes.[11][12][13]

Contents

  • Central nervous system constituent 1
  • Metabolic synthesis 2
  • Potential health effects 3
    • Alzheimer's disease and decline of mental health 3.1
    • Cancer 3.2
    • Pregnancy and lactation 3.3
    • Current research 3.4
  • Nutrition 4
    • Discovery of algae-based DHA 4.1
    • Use as a food additive 4.2
    • Studies of vegetarians and vegans 4.3
    • DHA and EPA in fish oils 4.4
      • Oxidation levels of available fish oils 4.4.1
  • Hypothesized role in human evolution 5
  • See also 6
  • References 7
  • External links 8

Central nervous system constituent

DHA is the most abundant omega-3 fatty acid in the brain and retina. DHA comprises 40% of the polyunsaturated fatty acids (PUFAs) in the brain and 60% of the PUFAs in the retina. Fifty percent of the weight of a neuron's plasma membrane is composed of DHA.[14] DHA is richly supplied during breastfeeding, and DHA levels are high in breastmilk regardless of dietary choices.

DHA modulates the carrier-mediated transport of choline, glycine, and taurine, the function of delayed rectifier potassium channels, and the response of rhodopsin contained in the synaptic vesicles, among many other functions.[15]

DHA deficiency is associated with cognitive decline.[16] Phosphatidylserine (PS) controls apoptosis, and low DHA levels lower neural cell PS and increase neural cell death.[17] DHA levels are reduced in the brain tissue of severely depressed patients.[18][19]

Metabolic synthesis

In humans, DHA is either obtained from the diet or may be converted in small amounts from eicosapentaenoic acid (EPA, 20:5, ω-3) via docosapentaenoic acid (DPA, 22:5 ω-3) as an intermediate.[6][7] This synthesis had been thought to occur through an elongation step followed by the action of Δ4-desaturase.[7] It is now considered more likely that DHA is biosynthesized via a C24 intermediate followed by beta oxidation in peroxisomes. Thus, EPA is twice elongated, yielding 24:5 ω-3, then desaturated to 24:6 ω-3, then shortened to DHA (22:6 ω-3) via beta oxidation. This pathway is known as Sprecher's shunt.[20][21]

Potential health effects

Alzheimer's disease and decline of mental health

Preclinical studies indicate that DHA improves memory,[22][23] can slow the progression of Alzheimer's disease neuropathology in mice,[24][25] sparking interest in additional research. However, the first large-scale human trials showed that DHA did not slow decline of mental function in elderly people with mild to moderate Alzheimer's disease.[26] These trials were part of a large US National Institutes of Health (NIH) intervention study to evaluate DHA in Alzheimer's disease.[27]

Researchers from the National Institute on Aging supported Alzheimer's Disease Cooperative Study and conducted a clinical trial comparing DHA and placebo over 18 months in 402 people (average age=76) diagnosed with mild to moderate Alzheimer's disease.[26] Treatment with DHA increased blood levels of DHA, and appeared to increase brain DHA levels, based on a measured increase of DHA in study participants' cerebrospinal fluid.

However, DHA treatment did not slow the rate of change on tests of mental function, global dementia severity status, activities of daily living, or behavioral symptoms in the study population as a whole. Treatment effects did not differ between the mild and moderate Alzheimer's patients, leading study authors to conclude that the results do not support the routine use of DHA for patients with Alzheimer's.[26]

Animal studies in the various transgenic mouse models of Alzheimer's disease had linked dietary DHA to decreases in amyloid plaques and tau.[28][29] Animal studies also showed, when DHA was combined with arachidonic acid (AA or ARA, also present in fish oil), plaque formation was greater with the arachidonic acid compared to DHA alone.

DHA deficiency likely plays a role in decline of mental function in healthy adults, which is indicated in a study from 2010 conducted at 19 U.S. clinical sites on 485 subjects aged 55 and older who met criteria for age-associated memory impairment. The study found algal DHA taken for six months decreased heart rate and improved memory and learning in healthy, older adults with mild memory complaints. These findings indicate the importance of early DHA intervention and provided a statistically significant benefit to cognitive function in individuals over 50 years of age.[30][31]

Higher DHA levels in middle-aged adults is related to better performance on tests of nonverbal reasoning and mental flexibility, working memory, and vocabulary.[32] DHA is the majority component of a Souvenaid, an oral supplement developed by MIT scientists that has been shown to modestly improve memory in subjects with early Alzheimer’s disease while showing insignificant benefits in other tests of cognitive function.[33][34]

The use of DHA by persons with epilepsy could decrease the frequency of their seizures. Studies have shown that children with epilepsy had a major improvement, i.e. decrease in the frequency of their seizures, but another study showed mixed results with 57 adults taking DHA supplementation. The 57 subjects demonstrated a decreased frequency of seizures for the first six weeks of the study, but for some it was just a temporary improvement.[35]

Docosahexaenoic acid may help in the prevention of aluminum induced biochemical and morphological alteration to the cerebellum.[36] A study from 2015 links the brain translocation of aluminium particles to a Trojan-horse mechanism that obeys to CCL2, signaling the major inflammatory monocyte chemoattractant.[37] CCL2 expression in glial cells is increased in patients with AD, showing the possible benefit of DHA in preventing, and likely treating, the disease.[38]

Cancer

In mice, DHA was found to inhibit growth of human colon carcinoma cells,[39][40] more than other omega-3 PUFAs. The cytotoxic effect of DHA was not caused by increased lipid peroxidation or any other oxidative damage, but rather a decrease in cell growth regulators. However, different cancer lines may handle PUFAs differently and display different sensitivities toward them.

DHA was shown to increase the efficacy of chemotherapy in prostate cancer cells in vitro,[41] and a chemoprotective effect in a mouse model was reported.[42] By contrast, one case-control study nested within a clinical trial originally designed to test the effect of finasteride on prostate cancer occurrence, the "Prostate Cancer Prevention Trial", found that DHA measured in blood serum was associated with an increase in high-grade prostate cancer risk.[43] In addition to DHA's possible anticancer effect, it may also be used as a non-toxic adjuvant to increase the efficacy of chemotherapy.[44]

Pregnancy and lactation

It has been recommended to eat foods which are high in omega-3 fatty acids for women who want to become pregnant or when nursing.[45] DHA has recently gained attention as a supplement for pregnant women, noting studies of improved attention and visual acuity. Given the recently gained attention, the majority of pregnant women in the U.S. fail to get the recommended amount of DHA in their diets. A working group from the International Society for the Study of Fatty Acids and Lipids recommended 300 mg/day of DHA for pregnant and lactating women, whereas the average consumption was between 45 mg and 115 mg per day of the women in the study, similar to a Canadian study.[46]

One study suggests that women who take DHA supplements during pregnancy give their babies some degree of added protection against getting common colds.[47]

DHA concentrations in breast milk range from 0.07% to greater than 1.0% of total fatty acids, with a mean of about 0.34%.

Current research

Although most studies demonstrate positive effects of dietary DHA on human health, some studies show little or no effect. For example, one study found that the use of DHA-rich fish oil capsules did not reduce postpartum depression in mothers or improve cognitive and language development in their offspring during early childhood.[48]

Additional studies confirmed DHA benefits for other nervous system functions,

Saturated
ω−3 Unsaturated
ω−6 Unsaturated
ω-7 Unsaturated
ω−9 Unsaturated
Index of biochemical
Other


  • DHA / EPA Omega-3 Institute – Recent studies, overviews, and objective science.
  • Docosahexaenoic acid (DHA) – University of Maryland Medical Center (UMMC)
  • Docosahexaenoic acid - DHA ChemSub Online

External links

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  2. ^ http://www.websters-online-dictionary.org/definitions/Docosahexaenoic%20Acids
  3. ^ The omega end is the one furthest from the carboxyl group.
  4. ^ Martek Biosciences Corporation (5 April 2007). "History of Martek". Archived from the original on February 5, 2007. Retrieved March 10, 2007. 
  5. ^ Martek Biosciences Corporation (29 July 2008). "Martek Products". Archived from the original on June 12, 2008. Retrieved July 29, 2008. 
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  7. ^ a b c Burdge, G. C.; Jones, A. E.; Wootton, S. A. (2002). "Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men". British Journal of Nutrition 88 (4): 355–363.  
  8. ^ Malone, J. P. (2011, August). Autistogenesis: A systems theory with evolutionary perspective. Poster presented at the American Psychological Association 119th Annual Convention, Washington, D.C. Abstract retrieved from http://forms.apa.org/convention/viewabstract.cfm?id=110999.
  9. ^ a b Giltay, E.J., Gooren, L. J. G., Toorians, A. W. F. T., Katan, M. B., & Zock, P. L. (2004). Docosahexanoic acid concentrations are higher in women than in men because of estrogenic effects. American Journal of Clinical Nutrition, 80(5), 1167-1174. Retrieved from http://www.ajcn.org/cgi/reprint/80/5/1167
  10. ^ Gary J. Nelson, Darshan S. Kelley. "DHA Lowers Blood Triglycerides in Diet Study" (PDF). Agricultural Research (USDA). Retrieved September 1998. 
  11. ^  
  12. ^ O'Connor, Anahad (March 30, 2015). "Fish Oil Claims Not Supported by Research".  
  13. ^ Grey, Andrew; Bolland, Mark (March 2014). "Clinical Trial Evidence and Use of Fish Oil Supplements".  
  14. ^ Meharban Singh (March 2005). "Essential Fatty Acids, DHA and the Human Brain from the Indian Journal of Pediatrics, Volume 72" (PDF). Retrieved October 8, 2007. 
  15. ^ Arthur A. Spector (1999). "Essentiality of Fatty Acids from Lipids, Vol. 34". Retrieved October 8, 2007. 
  16. ^ Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, Gotlinger K, Serhan CN, Bazan NG.; Cui; Marcheselli; Bodker; Botkjaer; Gotlinger; Serhan; Bazan (October 2005). "A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease". J Clin Invest. 115 (10): 2774–83.  
  17. ^ Serhan CN, Gotlinger K, Hong S, Arita M; Gotlinger; Hong; Arita (2004). "Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis". Prostaglandins Other Lipid Mediat. 73 (3–4): 155–72.  
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  19. ^ McNamara, R. K.; Jandacek, R; Tso, P; Dwivedi, Y; Ren, X; Pandey, G. N. (2013). "Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease". Journal of Psychiatric Research 47 (9): 1187–91.  
  20. ^ De Caterina, R and Basta, G (June 2001). "n-3 Fatty acids and the inflammatory response – biological background". European Heart Journal Supplements 3 (Supplement D): D42–D49.  
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  22. ^ Arsenault, Dany,; Carl Julien; et al. (2011). "DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice". PLoS ONE 6 (2): e17397.  
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  24. ^ "DHA Fights Alzheimer’s Brain Plaques in Mice". US Department of Veterans Affairs. 
  25. ^ Lim, Giselle; Frederic Calon; et al. (March 23, 2005). "A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model" (PDF). The Journal of Neuroscience. 
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  27. ^ National Institute on Aging (July 16, 2007). "DHA Phase 3 trial in Alzheimer's disease". Retrieved August 10, 2007. 
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  29. ^ Joffre, Corinne; A Nadjar; et al. (2014). "n-3 LCPUFA improves cognition: the young, the old and the sick". Prostaglandins Leukot Essent Fatty Acids 91 (1–2): 1–20.  
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  32. ^ Matthew, Muldoon; Christopher M. Ryan; Lei Sheu; Jeffrey K. Yao; Sarah M. Conklin; Stephen B. Manuck (January 28, 2010). "Serum Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning during Middle Adulthood". Journal of Nutrition 140 (4): 848–53.  
  33. ^ "MIT nutrient mixture improves memory in early Alzheimer’s". CenterWatch News Online. 10 July 2012. Retrieved 14 June 2014. 
  34. ^ Scheltens, P; Twisk, J. W.; Blesa, R; Scarpini, E; von Arnim, C. A.; Bongers, A; Harrison, J; Swinkels, S. H.; Stam, C. J.; De Waal, H; Wurtman, R. J.; Wieggers, R. L.; Vellas, B; Kamphuis, P. J. (2012). "Efficacy of Souvenaid in mild Alzheimer's disease: Results from a randomized, controlled trial". Journal of Alzheimer's disease : JAD 31 (1): 225–36.  
  35. ^ Yuen, A. W.; Sander, J. W.; Fluegel, D; Patsalos, P. N.; Bell, G. S.; Johnson, T; Koepp, M. J. (2005). "Omega-3 fatty acid supplementation in patients with chronic epilepsy: A randomized trial". Epilepsy & Behavior 7 (2): 253–8.  
  36. ^ http://www.ncbi.nlm.nih.gov/pubmed/25206046
  37. ^ http://www.ncbi.nlm.nih.gov/pubmed/25699008
  38. ^ https://www.ncbi.nlm.nih.gov/pubmed/20205643
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  40. ^ Schønberg SA, Lundemo AG, Fladvad T, Holmgren K, Bremseth H, Nilsen A, Gederaas O, Tvedt KE, Egeberg KW, Krokan HE; Lundemo; Fladvad; Holmgren; Bremseth; Nilsen; Gederaas; Tvedt; Egeberg; Krokan (2006). "Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1". Cancer Lett. 273 (12): 2749–65.  
  41. ^ Shaikh IAA, Brown I, Schofield AC, Wahle KWJ, Heys SD; Brown; Schofield; Wahle; Heys (November 2008). "Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway". Prostate. 68 (15): 1635–1646.  
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  48. ^ Maria Makrides, "The Effects of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children." The Journal of American Medical Association http://jama.ama-assn.org/content/304/15/1675.abstract
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References

See also

An abundance of DHA in seafood has been suggested as being helpful in the development of a large brain,[71] though other researchers claim a terrestrial diet could also have provided the necessary DHA.[72]

Hypothesized role in human evolution

A recent study has revealed that "Fish oil supplements in New Zealand are highly oxidised and do not meet label content of n-3 PUFA" [69] In another study "Oxidation of Marine Omega-3 Supplements and Human Health", the authors note: "It is currently impossible to determine how oxidation affects the efficacy or potential harms of marine oil. This makes interpretation of the clinical trial literature problematic. If the oxidative state of marine oils may affect efficacy or harm, then physicians should recommend, and consumers select, a supplement with the same oxidative state as the oils used in clinical trials that have shown benefit and safety."[70]

Oxidation levels of available fish oils

Fish oil is widely sold in gelatin capsules containing a mixture of omega-3 fatty acids including EPA and smaller quantities of DHA. One study found that fish oil higher in EPA than DHA lowered inflammatory cytokines, such as IL-6 and IL-1β, associated with neurodegenerative and autoimmune diseases. They note the brain normally contains DHA, but not EPA, though both DHA and EPA plasma concentrations increased significantly for participants.[68]

DHA and EPA in fish oils

Vegetarian diets typically contain limited amounts of DHA, and vegan diets typically contain no DHA. A supplemental DHA, available in algae-derived oils or capsules, has been shown to increase DHA levels. While there is little evidence of adverse health or cognitive effects due to DHA deficiency in adult vegetarians or vegans, fetal and breast milk levels remain a concern.[67]

Studies of vegetarians and vegans

DHA is believed to be helpful to people with a history of heart disease, for premature infants, and to support healthy brain development especially in young children along with supporting retinal development. Some manufactured DHA is a vegetarian product extracted from algae, and it competes on the market with fish oil that contains DHA and other omega-3's such as EPA. Both fish oil and DHA are odorless and tasteless after processing as a food additive.[66]

DHA is widely used as a food supplement. It was first used primarily in infant formulas.[64] In 2004, the US Food and Drug Administration endorsed qualified health claims for DHA,[65] and by 2007 DHA-fortified dairy items (milk, yogurt, cooking oil) started to appear in grocery stores.

Use as a food additive

In the early 1980s, NASA sponsored scientific research in search of a plant-based food source that could generate oxygen and nutrition on long-duration space flights. The researchers discovered that certain species of marine algae produced rich nutrients. This research led to the development of an algae-based, vegetable-like oil that contains two essential polyunsaturated fatty acids, DHA and ARA (arachidonic acid),[62] which can now be found in health supplements.[63]

Discovery of algae-based DHA

Diets that consist of high doses of omega-3 fatty acids help prevent strokes. There are fewer strokes in countries where people consume high amounts of omega-3 fatty acids, such as Japan and Sweden.

Ordinary types of cooked salmon contain 500–1500 mg DHA and 300–1000 mg EPA per 100 grams.[61] Additional top fish sources of DHA include tuna, bluefish, mackerel, swordfish, anchovies, herring, sardines, and caviar.

Algae-based DHA supplements

Nutrition

Researchers in Norway are testing a treatment for psoriasis with a synthesised molecule based on DHA.[60]

[59] Because humans and other mammals are able to make their own DHA from other fatty acids, DHA deficiency is not common. But, if that DHA-synthesizing enzyme is defective, it could lead to problems with infertility.[58], an arc-like structure on the top of sperm, which is critical in fertilization because it houses a variety of enzymes that sperm use to penetrate an egg.acrosome According to a new study, DHA is very likely important in the formation of the
[57] Accordingly, dietary administration of DHA reduces stroke-induced neuroinflammation in animal models.[56] Lastly, in preliminary research, it was found that a diet rich in DHA might protect stroke victims from brain damage and disability and aid in a speedier recovery.[55] It is now considered so important to brain and eye development that DHA is included in most infant formulas.[54] consistent with DHA being the most abundant omega-3 fatty acid in the brain. Neuroprotective effects of dietary DHA have been described in animals models of Parkinson's disease.[53] and Parkinson's disease[52] Preliminary studies showed that a high intake of DHA was associated with reduced risk for developing Alzheimer's disease[51] shortening, which is a basic DNA-level marker of aging.telomere A new study found that higher intake of DHA was associated with slower rates of [50] Higher intakes of DHA and EPA may reduce the risk of cardiovascular diseases.[49]

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