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Docosatetraenoylethanolamide

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Title: Docosatetraenoylethanolamide  
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Subject: Stearoylethanolamide, Arachidonoyl serotonin, Oleoylethanolamide, 2-Arachidonyl glyceryl ether, Virodhamine
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Docosatetraenoylethanolamide

Docosatetraenoylethanolamide
Identifiers
CAS number  N
PubChem
ChemSpider  YesY
ChEMBL  YesY
Jmol-3D images Image 1
Properties
Molecular formula C24H41NO2
Molar mass 375.59 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Docosatetraenoylethanolamide (DEA) is an endogenous ethanolamide that has been shown to act on the cannabinoid (CB1) receptor.[1] DEA is similar in structure to anandamide (AEA, a recognized endogenous ligand for the CB1 receptor), containing docosatetraenoic acid in place of arachidonic acid. While DEA has been shown to bind to the CB1 receptor with similar potency and efficacy as AEA, its role as a cannabinergic neurotransmitter is not well understood.

References

  1. ^ Hanus, L., Gopher, A., Almog, S., et al. (1993). "Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor". J Med Chem 36 (20): 3032–3034.  


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