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Title: Dopastin  
Author: World Heritage Encyclopedia
Language: English
Subject: List of dopaminergic drugs, Catecholaminergic, D-161, Sercloremine, 3-Iodotyrosine
Publisher: World Heritage Encyclopedia


CAS number
Jmol-3D images Image 1
Molecular formula C9H17N3O3
Molar mass 215.25 g mol−1
Melting point 116 to 119 °C (241 to 246 °F; 389 to 392 K)[1]
Acidity (pKa) 5.1[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)

Dopastin is a chemical compound produced by the bacteria Pseudomonas No. BAC-125.[2] It was first isolated and characterized in 1972. It is an inhibitor of the enzyme dopamine β-hydroxylase.[3]

Dopastin can be prepared synthetically from L-valinol.[4]


  1. ^ a b Merck Index, 11th Edition, 3417
  2. ^ Iimura, H; Takeuchi, T; Kondo, S; Matsuzaki, M; Umezawa, H (1972). "Dopastin, an inhibitor of dopamine -hydroxylase". The Journal of antibiotics 25 (8): 497–500.  
  3. ^ H. Iinuma; M. Matsuzaki; T. Nagatsu; T. Takeuchi; H. Umezawa (1974). "Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase". Agric. Biol. Chem. 38 (11): 2107–2111.  
  4. ^ Ohno, M.; Iinuma, H.; Yagisawa, N.; Shibahara, S.; Suhara, Y.; Kondo, S.; Maeda, K.; Umezawa, H. (1973). "Synthesis of dopastin, a dopamine ?-hydroxylase inhibitor of microbial origin". Journal of the Chemical Society, Chemical Communications (4): 147.  
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